thebarkerlab

Toll-interacting protein impacts on inflammation, autophagy

Posted on by Robert

Toll-interacting protein impacts on irritation, autophagy, and vacuole trafficking in human illness

Toll-interacting protein (TOLLIP) is a ubiquitous intracellular adaptor protein concerned in a number of intracellular signaling pathways. It performs a key position in mediating inflammatory intracellular responses, selling autophagy, and enabling vacuole transport throughout the cell. TOLLIP is being more and more acknowledged for its position in illness pathophysiology by way of involvement in these three main pathways. Current analysis additionally signifies that TOLLIP is concerned in nuclear-cytoplasmic switch, though this space requires additional exploration. TOLLIP is concerned within the pathophysiologic pathways related to neurodegenerative ailments, pulmonary ailments, heart problems, inflammatory bowel illness, and malignancy.

We postulate that TOLLIP performs an integral position within the illness pathophysiology of different situations concerned in vacuole trafficking and autophagy. We propose that future analysis on this discipline ought to examine the position of TOLLIP antibodies within the pathogenesis of those a number of situations.

This analysis has the potential to tell illness mechanisms and determine novel alternatives for therapeutic advances in a number of illness processes

Molecular docking-assisted screening reveals tannic acid as a pure protein disulphide isomerase inhibitor with antiplatelet and antithrombotic actions

Protein disulphide isomerase (PDI) promotes platelet activation and constitutes a novel antithrombotic goal. On this examine, we reported {that a} PDI-binding plant polyphenol, tannic acid (TA), inhibits PDI exercise, platelet activation and thrombus formation.

Molecular docking utilizing plant polyphenols from dietary sources with cardiovascular advantages revealed TA as probably the most potent binding molecule with PDI energetic centre. Floor plasmon resonance demonstrated that TA certain PDI with excessive affinity. Utilizing Di-eosin-glutathione disulphide fluorescence assay and PDI assay package, we confirmed that TA inhibited PDI exercise.

In remoted platelets, TA inhibited platelet aggregation stimulated by both GPVI or ITAM pathway agonists. Stream cytometry confirmed that TA inhibited thrombin- or CRP-stimulated platelet activation, as mirrored by diminished granule secretion and integrin activation. TA additionally diminished platelet spreading on immobilized fibrinogen and platelet adhesion below move situations.

In a laser-induced vascular harm mouse mannequin, intraperitoneal injection of TA considerably decreased the dimensions of cremaster arteriole thrombi. No prolongation of mouse jugular vein and tail-bleeding time was noticed after TA administration. Due to this fact, we recognized TA from pure polyphenols as a novel inhibitor of PDI perform. TA inhibits platelet activation and thrombus formation, suggesting it as a possible antithrombotic agent.

thebarkerlab
thebarkerlab

Cellufine PB
683-986-330 5 lt Ask for price

Cellufine PB
683-986-335 10 lt Ask for price

Cellufine Formyl
20-854 500 ml
EUR 4890

Cellufine Formyl
676-944-324 10 ml
EUR 388.8

Cellufine Formyl
676-944-335 10 lt Ask for price

Cellufine Formyl
19-853 50 ml
EUR 644.4

Cellufine Formyl
21-855 5 lt Ask for price

Cellufine Sulfate
676-943-324 10 ml
EUR 362.4

Cellufine Sulfate
19845 50 ml
EUR 669.6

Cellufine Sulfate
19846 500 ml
EUR 3470.4

Cellufine Sulfate
19847 5 lt Ask for price

Cellufine Sulfate
19849 10 lt Ask for price

Cellufine Phosphate
684-987-335 10 lt Ask for price

Cellufine Phosphate
685-987-330 5 lt Ask for price

Cellufine Phosphate
19-524 10 ml
EUR 516

Cellufine Phosphate
19-545 50 ml
EUR 542.4

Cellufine Phosphate
19-546 500 ml
EUR 4046.4

MC Cellufine PB
202-15 1 x 5 ml
EUR 542.4

MC Cellufine PB
202-51 5 x 1 ml
EUR 542.4

Cellufine MAX GS
21-300 100 ml
EUR 606

Cellufine MAX GS
21-301 500 ml
EUR 1962

Cellufine MAX GS
21-302 5 lt Ask for price

Cellufine MAX GS
21-303 10 lt Ask for price

Cellufine MAX IB
21-600 10 ml
EUR 312

Cellufine MAX IB
21-601 50 ml
EUR 580.8

Cellufine MAX IB
21-602 100 ml
EUR 753.6

Cellufine MAX IB
21-603 500 ml
EUR 2882.4

Cellufine MAX IB
21-604 5 lt Ask for price

Cellufine MAX IB
21-605 10 lt Ask for price

Cellufine GH-25
670000327 100 ml
EUR 362.4

Cellufine GH-25
670000335 10 lt Ask for price

Cellufine A-800
673980327 100 ml
EUR 388.8

Cellufine A-800
673980335 10 lt Ask for price

Cellufine A-500
675980327 100 ml
EUR 388.8

Cellufine A-500
675980335 10 lt Ask for price

Cellufine Q-500
675982327 100 ml
EUR 439.2

Cellufine Q-500
675982335 10 lt Ask for price

Cellufine C-500
675983327 100 ml
EUR 388.8

Cellufine C-500
675983335 10 lt Ask for price

Cellufine A-200
676-980-327 100 ml
EUR 388.8

Cellufine A-200
676980335 10 lt Ask for price

Cellufine A-200
19611 500 ml
EUR 631.2

Cellufine A-200
19612 5 lt Ask for price

Cellufine GH-25
19712 5 lt Ask for price

Cellufine A-800
19800 500 ml
EUR 631.2

Cellufine A-800
19801 5 lt Ask for price

Cellufine A-500
19805 500 ml
EUR 631.2

Cellufine A-500
19806 5 lt Ask for price

Cellufine C-500
19865 500 ml
EUR 631.2

Cellufine C-500
19866 5 lt Ask for price

Cellufine S-500
21-200 100 ml
EUR 465.6

Cellufine S-500
21-201 500 ml
EUR 836.4

Cellufine S-500
21-202 5 lt Ask for price

Cellufine S-500
21-203 10 lt Ask for price

Cellufine Q-500
19907 500 ml
EUR 861.6

Cellufine Q-500
19908 5 lt Ask for price

Cellufine MAX DEAE
21-000 100 ml
EUR 458.4

Cellufine MAX DEAE
21-001 500 ml
EUR 1756.8

Cellufine MAX DEAE
21-002 5 lt Ask for price

Cellufine MAX DEAE
21-003 10 lt Ask for price

Cellufine SPA-HC
21-900 10 ml
EUR 823.2

Cellufine SPA-HC
21-901 50 ml
EUR 1635.6

Cellufine SPA-HC
21-902 500 ml
EUR 8228.4

Cellufine SPA-HC
21-903 5 lt Ask for price

Cellufine SPA-HC
21-904 10 lt Ask for price

Cellufine MAX Butyl
21-100 100 ml
EUR 439.2

Cellufine MAX Butyl
21-101 500 ml
EUR 1194

Cellufine MAX Butyl
21-102 5 lt Ask for price

Cellufine MAX Butyl
21-103 10 lt Ask for price

Cellufine ETclean L
681-984-324 10 ml
EUR 439.2

Cellufine ETclean L
681-984-326 50 ml
EUR 708

Cellufine ETclean L
681-984-328 500 ml
EUR 3624

Cellufine ETclean L
681-984-330 5 lt Ask for price

Cellufine ETclean L
681-984-335 10 lt Ask for price

Cellufine ETclean S
682-985-324 10 ml
EUR 439.2

Cellufine ETclean S
682-985-326 50 ml
EUR 708

Cellufine ETclean S
682-985-328 500 ml
EUR 3624

Cellufine ETclean S
682-985-330 5 lt Ask for price

Cellufine ETclean S
682-985-335 10 lt Ask for price

MC Cellufine Sulfate
19-845-15 1 x 5 ml
EUR 439.2

MC Cellufine Sulfate
19-845-51 5 x 1 ml
EUR 439.2

Cellufine MAX Phenyl
20700 100 ml
EUR 439.2

Cellufine MAX Phenyl
20701 500 ml
EUR 1194

Cellufine MAX Phenyl
20702 5 lt Ask for price

Cellufine MAX Phenyl
20703 10 lt Ask for price

MC Cellufine Phosphate
195-15 1 x 5 ml
EUR 516

MC Cellufine Phosphate
195-51 5 x 1 ml
EUR 516

Cellufine GCL-2000HF
21-400 100 ml
EUR 362.4

Cellufine GCL-2000HF
21-401 500 ml
EUR 542.4

Cellufine GCL-2000HF
21-402 5 lt Ask for price

Cellufine GCL-2000HF
21-403 10 lt Ask for price

Cellufine MAX S-r
20-300 100 ml
EUR 458.4

Cellufine MAX S-r
20-301 500 ml
EUR 1756.8

Cellufine MAX S-r
20-302 5 lt Ask for price

Cellufine MAX S-r
20-303 10 lt Ask for price

Cellufine MAX S-h
20-400 100 ml
EUR 458.4

Cellufine MAX S-h
20-401 500 ml
EUR 1756.8

Cellufine MAX S-h
20-402 5 lt Ask for price

Cellufine MAX S-h
20-403 10 lt Ask for price

Cellufine MAX Q-r
20-500 100 ml
EUR 458.4

Cellufine MAX Q-r
20-501 500 ml
EUR 1756.8

Cellufine MAX Q-r
20-502 5 lt Ask for price

Cellufine MAX Q-r
20-503 10 lt Ask for price

Cellufine MAX Q-h
20-600 100 ml
EUR 458.4

Cellufine MAX Q-h
20-601 500 ml
EUR 1756.8

Cellufine MAX Q-h
20-602 5 lt Ask for price

Cellufine MAX Q-h
20-603 10 lt Ask for price

MC Cellufine MAX CM
20-900 100 ml
EUR 458.4

MC Cellufine MAX CM
20-900-51 5 x 1 ml
EUR 325.2

MC Cellufine MAX CM
20-900-55 5 x 5 ml
EUR 631.2

MC Cellufine MAX CM
20-901 500 ml
EUR 1756.8

MC Cellufine MAX CM
20-902 5 lt Ask for price

MC Cellufine MAX CM
20-903 10 lt Ask for price

MC Cellufine MAX GS
21-300-51 5 x 1 ml
EUR 325.2

MC Cellufine MAX GS
21-300-55 5 x 5 ml
EUR 631.2

MC Cellufine MAX IB
21-600-15 1 x 5 ml
EUR 362.4

MC Cellufine MAX IB
21-600-51 5 x 1 ml
EUR 362.4

MC Cellufine A-200
19-611-51 5 x 1 ml
EUR 260.4

MC Cellufine GH-25
19-711-55 5 x 5 ml
EUR 516

MC Cellufine C-500
19-800-51 5 x 1 ml
EUR 260.4

MC Cellufine C-500
19-800-55 5 x 5 ml
EUR 414

MC Cellufine A-500
19-805-51 5 x 1 ml
EUR 260.4

MC Cellufine A-500
19-805-55 5 x 5 ml
EUR 414

MC Cellufine A-800
19-865-51 5 x 1 ml
EUR 260.4

MC Cellufine A-800
19-865-55 5 x 5 ml
EUR 414

MC Cellufine Q-500
19-907-51 5 x 1 ml
EUR 260.4

MC Cellufine Q-500
19-907-55 5 x 5 ml
EUR 414

MC Cellufine S-500
21-200-51 5 x 1 ml
EUR 286.8

MC Cellufine S-500
21-200-55 5 x 5 ml
EUR 504

MC Cellufine MAX DEAE
21-000-51 5 x 1 ml
EUR 325.2

MC Cellufine MAX DEAE
21-000-55 5 x 5 ml
EUR 631.2

MC Cellufine SPA-HC
21-900-11 1 x 1 ml
EUR 446.4

MC Cellufine SPA-HC
21-900-15 1 x 5 ml
EUR 663.6

MC Cellufine SPA-HC
21-900-51 5 x 1 ml
EUR 663.6

MC Cellufine MAX Butyl
21-100-51 5 x 1 ml
EUR 325.2

MC Cellufine MAX Butyl
21-100-55 5 x 5 ml
EUR 644.4

MC Cellufine MAX Phenyl
20-700-51 5 x 1 ml
EUR 325.2

MC Cellufine MAX Phenyl
20-700-55 5 x 5 ml
EUR 644.4

Cellufine MAX Phenyl LS
20800 100 ml
EUR 439.2

Cellufine MAX Phenyl LS
20801 500 ml
EUR 1194

Cellufine MAX Phenyl LS
20802 5 lt Ask for price

Cellufine MAX Phenyl LS
20803 10 lt Ask for price

MC Cellufine Etclean S
201-15 1 x 5 ml
EUR 427.2

MC Cellufine Etclean S
201-51 5 x 1 ml
EUR 427.2

The newest developments in imaging fibroblast activation protein (FAP)

Fibroblast activation protein (FAP), a membrane-anchored peptidase, is extremely expressed in cancer-associated fibroblasts (CAFs) in additional than 90% of epithelial tumors and contributes to development and worse prognosis of various cancers. Due to this fact, FAP is taken into account a promising goal for radionuclide-based approaches for analysis and therapy of tumors and for the analysis of non-malignant ailments related to a reworking of the extracellular matrix.
Accordingly, a wide range of quinolone-based FAP inhibitors (FAPI) coupled to chelators had been developed displaying particular binding to human and murine FAP with a speedy and nearly full internalization. On account of a excessive tumor uptake and a really low accumulation in regular tissues in addition to a speedy clearance from the circulation, a high-contrast is obtained for FAPI-PET/CT imaging even at 10 minutes after tracer administration.
Furthermore, FAPI-PET/CT gives benefits over FDG-PET/CT in a number of tumor entities for preliminary staging and detection of tumor recurrence and metastases together with peritonitis carcinomatosa.

Autoimmunity linked protein phosphatase PTPN22 as a goal for most cancers immunotherapy

Background: Most cancers immunotherapy has advanced from interferon-alpha (IFNα) and interleukin-2 within the 1980s to CTLA-Four and PD-1/PD-L1 checkpoint inhibitors (CPIs), the latter highlighting the significance of enhancing T-cell features.
Whereas the seek for novel immunomodulatory pathways continues, mixture therapies augmenting a number of pathways may enhance efficacy. The affiliation of autoimmune-related antagonistic occasions with medical efficacy following CPI therapy has been inferred and means that breaking tolerance thresholds related to autoimmunity might have an effect on host immune responses for efficient most cancers immunotherapy.
Outcomes: Right here, we present that lack of autoimmune related PTPN22, a key desensitization node for a number of signaling pathways, together with IFNα receptor (IFNAR) and T-cell receptor, can increase tumor responses. Implantation of syngeneic tumors in Ptpn22-/- mice led to growth and activation of peripheral and intratumoral T cells and, in flip, spontaneous tumor regression in addition to enhanced responses together with anti-PD-L1 therapy.
Utilizing genetically modified mice expressing a catalytically inactive PTPN22 or the autoimmunity-associated human single-nucleotide polymorphism variant, augmentation of antitumor immunity was depending on PTPN22 phosphatase exercise and partially on its adaptor features.
Additional, antitumor responses had been depending on each CD4+ and CD8+T cells and, partly, IFNAR perform. Lastly, we reveal that the autoimmune susceptibility Ptpn22(C1858T) variant is related to decrease danger of creating non-melanoma pores and skin cancers, improved general survival and elevated danger for growth of hyperthyroidism or hypothyroidism following atezolizumab (anti-PD-L1) therapy.
Conclusions: Collectively, these knowledge recommend that inhibition of PTPN22 phosphatase exercise might present an efficient therapeutic possibility for most cancers immunotherapy and that exploring genetic variants that shift immune tolerance thresholds might function a paradigm for locating new most cancers immunotherapy targets.

Recombinant Proteins Co-Expressed and Co-Purified within the Presence of Antibody Fragments

Recombinant antibodies in single-domain format (VHHs) have been lately used for stabilizing antigens throughout their purification and crystallization. VHHs are additionally recognized for his or her structural stability and a big a part of them share the attribute of remaining functionally folded additionally within the absence of the interior disulfide bond.
Due to this fact, they are often expressed as intrabodies within the cell cytoplasm in addition to within the bacterial periplasm. This proof implies that, in idea, VHHs may be co-expressed with their antigens independently on the redox constrains.
It has additionally urged the concept of utilizing co-expression and co-purification of antigen-antibody complexes for maximizing the stabilizing impact of the antibody on its antigen throughout all of the manufacturing steps for each cytoplasmic and periplasmic expression methods.

An Orthogonal Fusion Tag for Environment friendly Protein Purification

On this chapter, we current an environment friendly methodology for stringent protein purification facilitated by a twin affinity tag known as ABDz1, which is predicated on a 5 kDa albumin-binding area from Streptococcal Protein G. The small fusion tag allows an orthogonal affinity purification method based mostly on two successive and extremely particular affinity purification steps.
This method is enabled by native binding of ABDz1 to human serum albumin and engineered binding to Staphylococcal Protein A, respectively. The ABDz1-tag may be fused to both terminus of a protein of curiosity and the purification steps may be carried out utilizing commonplace laboratory gear.

MIP-3 beta Antibody (Biotin)
GWB-F27803 0.05 mg Ask for price

Recombinant CCL19 (MIP-3β)
MBS197063-0005mg 0.005mg
EUR 175

Recombinant CCL19 (MIP-3β)
MBS197063-002mg 0.02mg
EUR 285

Recombinant CCL19 (MIP-3β)
MBS197063-005mg 0.05mg
EUR 405

Recombinant CCL19 (MIP-3β)
MBS197063-01mg 0.1mg
EUR 605

Recombinant CCL19 (MIP-3β)
MBS197063-1mg 1mg
EUR 2540

Recombinant Human MIP-3 beta
MBS7611183-005mg 0.05mg
EUR 345

Recombinant Human MIP-3 beta
MBS7611183-02mg 0.2mg
EUR 635

Recombinant Human MIP-3 beta
MBS7611183-1mg 1mg
EUR 1800

Recombinant Human MIP-3 beta
MBS7611183-5x1mg 5x1mg
EUR 6955

Recombinant Mouse MIP-3 beta
MBS7608911-005mg 0.05mg
EUR 345

Recombinant Mouse MIP-3 beta
MBS7608911-02mg 0.2mg
EUR 635

Recombinant Mouse MIP-3 beta
MBS7608911-1mg 1mg
EUR 1800

Recombinant Mouse MIP-3 beta
MBS7608911-5x1mg 5x1mg
EUR 6955

MIP-3 beta Recombinant Protein
40-354-0005mg 0.005 mg
EUR 311.1
Description: MIP-3 beta is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3 beta is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3 beta is active on murine cells. Recombinant murine MIP-3 beta is a 9.2 kDa protein containing 83 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

MIP-3 beta Recombinant Protein
40-354-002mg 0.02 mg
EUR 437.1
Description: MIP-3 beta is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3 beta is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3 beta is active on murine cells. Recombinant murine MIP-3 beta is a 9.2 kDa protein containing 83 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

MIP-3 beta Recombinant Protein
40-381-0005mg 0.005 mg
EUR 311.1
Description: MIP-3 beta is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3 beta is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3 beta is active on murine cells. Recombinant human MIP-3 beta is an 8.8 kDa protein containing 77 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

MIP-3 beta Recombinant Protein
40-381-002mg 0.02 mg
EUR 437.1
Description: MIP-3 beta is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3 beta is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3 beta is active on murine cells. Recombinant human MIP-3 beta is an 8.8 kDa protein containing 77 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Human MIP-3 beta ELISA Kit
K0332182 96well
EUR 271

Human MIP-3 beta ELISA Kit
GWB-SKR155 96 Tests Ask for price

RABBIT ANTI HUMAN MIP-3 BETA
MBS221727-01mg 0.1mg
EUR 635

RABBIT ANTI HUMAN MIP-3 BETA
MBS221727-5x01mg 5x0.1mg
EUR 2695

MIP-3 beta, CCL19, murine (mouse)
RC335-20 5ug
EUR 121.6

Anti-Human MIP-3 beta Antibody
102-P68 100 µg
EUR 245.7
Description: MIP-3β is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3β is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3β is active on mouse cells. Recombinant human MIP-3β is an 8.8 kDa protein containing 77 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Anti-Human MIP-3 beta Antibody
101-M80 500 µg
EUR 246.75
Description: MIP-3β is a CC chemokine, expressed in the thymus, lymph nodes, and in activated bone marrow stromal cells that signals through the CCR7 receptor. MIP-3β is a chemoattractant for T and B lymphocytes, and myeloid progenitor cells. Human MIP-3β is active on murine cells. Recombinant Murine MIP-3β is a 9.2 kDa protein containing 83 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

MIP-3 beta Recombinant Rabbit mAb
BS48616 50 ul
EUR 398
Description: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

MIP-3 beta Recombinant Rabbit mAb
BS48624 50 ul
EUR 398
Description: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Recombinant Human MIP-3 beta (CCL19)
MBS4159807-002mg 0.02mg
EUR 345

Recombinant Human MIP-3 beta (CCL19)
MBS4159807-1mg 1(mg)
EUR 4600

Recombinant Human MIP-3 beta (CCL19)
MBS4159807-5x1mg 5x1mg
EUR 20445

Recombinant Human MIP-3 beta (CCL19)
Z101945 20 µg
EUR 195
Description: CCL19 is a chemokine that belongs to the CC family of growth factors and signals through the CCR7 receptor. CCl19 has been shown to be expressed in the thymus, lymph nodes and in activated bone marrow stromal cells. When anti-inflammatory signals are released, expression of CCL19 gets down-regulated – specifically by IL-10.

Recombinant Human MIP-3 beta (CCL19)
Z101949 1.0 mg
EUR 3900
Description: CCL19 is a chemokine that belongs to the CC family of growth factors and signals through the CCR7 receptor. CCl19 has been shown to be expressed in the thymus, lymph nodes and in activated bone marrow stromal cells. When anti-inflammatory signals are released, expression of CCL19 gets down-regulated – specifically by IL-10.

Recombinant Murine MIP-3 beta /CCL19
MECCP-1901 5ug Ask for price

Recombinant Human MIP-1 beta （rHu MIP-1 beta /CCL4
JOT-PR1095 2µg
EUR 205
Description: Determined by its ability to chemoattract human blood monocytes using a concentration range of 5.0-20.0 ng/ml, corresponding to a Specific Activity of ＞5 x 104 IU/mg.

Recombinant Human MIP-1 beta （rHu MIP-1 beta /CCL4
PR1095 2µg
EUR 158
Description: Determined by its ability to chemoattract human blood monocytes using a concentration range of 5.0-20.0 ng/ml, corresponding to a Specific Activity of ＞5 x 104 IU/mg.

CCL19 / MIP-3 beta (Human) ELISA Kit
EK-045-68 96 wells
EUR 603.72

Human CCL19/MIP-3 Beta ELISA Kit
EK5194 96 tests
EUR 599

Mouse CCL19/MIP-3 beta ELISA Kit
EK5195 96 tests
EUR 599

Human CCL19/MIP-3 beta ELISA Kit
LF-EK50840 1×96T
EUR 777.6

Rat MIP-1 beta
MBS691673-0005mg 0.005mg
EUR 300

Rat MIP-1 beta
MBS691673-002mg 0.02mg
EUR 450

Rat MIP-1 beta
MBS691673-5x002mg 5x0.02mg
EUR 1725

Mouse MIP-1 beta
MBS691963-0002mg 0.002mg
EUR 300

Mouse MIP-1 beta
MBS691963-001mg 0.01mg
EUR 450

Mouse MIP-1 beta
MBS691963-5x001mg 5x0.01mg
EUR 1725

MIP-1 beta Antibody
GWB-185AB9 0.1 mg Ask for price

Anti-Ccl19/MIP-3 beta Picoband Antibody
MBS1750677-01mg 0.1mg
EUR 450

Anti-Ccl19/MIP-3 beta Picoband Antibody
MBS1750677-5x01mg 5x0.1mg
EUR 1870

MIP 1 beta antibody
MBS835136-INQUIRE INQUIRE Ask for price

Human MIP-3 beta (CCL19) Recombinant Protein
100-079 20 µg
EUR 196.35
Description: MIP-3β is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3β is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3β is active on murine cells. Recombinant human MIP-3β is an 8.8 kDa protein containing 77 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Human MIP-3 beta (CCL19) Recombinant Protein
100-079S 5 µg
EUR 92.4
Description: MIP-3β is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3β is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3β is active on murine cells. Recombinant human MIP-3β is an 8.8 kDa protein containing 77 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Recombinant Mouse MIP-3 Beta/CCL19 protein
CD00293-5ug 5ug
EUR 176
Description: CCL19, also known as EBI1 Ligands chemokine (ELC) and macrophage inflammatory protein-3-beta, is encoded by the CCL19 gene which is located on chromosome 4 in mouse. The protein is expressed at high levels in thymus and lymph nodes, with intermediate levels in trachea and colon and low levels in stomach, lung and some other organs. CCL19 is signal through CCR7 and chemotaxis of T and B lymphocytes and myeloid progenitor cells.

Mouse MIP-3 beta (CCL19) Recombinant Protein
M10-079 20 µg
EUR 196.35
Description: MIP-3β is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3β is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3β is active on murine cells. Mouse urine MIP-3β is a 9.2 kDa protein containing 83 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Mouse MIP-3 beta (CCL19) Recombinant Protein
M10-079S 5 µg
EUR 92.4
Description: MIP-3β is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3β is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3β is active on murine cells. Mouse urine MIP-3β is a 9.2 kDa protein containing 83 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Human CCL19/MIP-3 beta Recombinant Protein
PROTQ99731 Regular: 20ug
EUR 243
Description: Human CCL19/MIP-3 beta Recombinant Protein expressed in E. coli with T7-tag. Sequence domain: 22-98aa. Application(s): SDS-PAGE. Endotoxin: < 1 EU per 1ug of protein (determined by LAL method).

Recombinant Human MIP-3 Beta (CCL19) Protein
PROTQ99731-1 20ug
EUR 380.4
Description: MIP-3β is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3β is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3β is active on murine cells. Recombinant human MIP-3β is an 8.8 kDa protein containing 77 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Recombinant Human CCL19/MIP-3 beta Protein
RP01634 100μg
EUR 38.97

Recombinant Human CCL19/MIP-3 beta Protein
RP01832 10μg
EUR 364.88

Recombinant Murine MIP-3 Beta (CCL19) Protein
PROTO70460-2 20ug
EUR 380.4
Description: MIP-3β is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3β is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3β is active on murine cells. Recombinant murine MIP-3β is a 9.2 kDa protein containing 83 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

OPSD00071-5UG - Recombinant MIP-3 beta / CCL19
OPSD00071-5UG 5ug
EUR 108

OPSD00132-5UG - Recombinant MIP-3 beta / CCL19
OPSD00132-5UG 5ug
EUR 108

Mouse MIP-3 beta Recombinant Protein Lyophilized
IMSMIP3BRLY5UG each
EUR 341
Description: Mouse MIP-3 beta Recombinant Protein Lyophilized

Human MIP-3 beta Recombinant Protein Lyophilized
IHUMIP3BRLY5UG each
EUR 341
Description: Human MIP-3 beta Recombinant Protein Lyophilized

Human MIP-3 beta Recombinant Protein Lyophilized
MBS8432772-INQUIRE INQUIRE Ask for price

Mouse MIP-3 beta Recombinant Protein Lyophilized
MBS8434280-INQUIRE INQUIRE Ask for price

Mouse Anti-Human MIP-3 alpha (beta)
MBS690310-05mg 0.5mg
EUR 525

Mouse Anti-Human MIP-3 alpha (beta)
MBS690310-5x05mg 5x0.5mg
EUR 2080

Human MIP-3 beta ELISA Kit, pink-ONE
K0332182P 96well
EUR 299

Human CCL19/MIP-3 beta PicoKine ELISA Kit
MBS176518-5x96StripWells 5x96-Strip-Wells
EUR 2755

Human CCL19/MIP-3 beta PicoKine ELISA Kit
MBS176518-96StripWells 96-Strip-Wells
EUR 600

Mouse CCL19/MIP-3 beta PicoKine ELISA Kit
MBS177585-5x96StripWells 5x96-Strip-Wells
EUR 2755

Mouse CCL19/MIP-3 beta PicoKine ELISA Kit
MBS177585-96StripWells 96-Strip-Wells
EUR 600

MIP-1 beta, CCL4, rat
RC355-15 5ug
EUR 125.26

OKRC00720-96W - MIP-3 beta ELISA Kit (Human)
OKRC00720-96W 96Wells
EUR 525

OKRC01262-96W - MIP-3 beta ELISA Kit (Mouse)
OKRC01262-96W 96Wells
EUR 525

Human MIP-1 beta (CCL4)
MBS692135-0002mg 0.002mg
EUR 300

Human MIP-1 beta (CCL4)
MBS692135-001mg 0.01mg
EUR 450

Human MIP-1 beta (CCL4)
MBS692135-5x001mg 5x0.01mg
EUR 1725

MIP-1 beta, CCL4, human
RC314-15 2ug
EUR 121.6

Rabbit Anti Human Mip-3 Beta Polyclonal Antibody
CPBT-65218RH 0.1 mg
EUR 659.4
Description: Rabbit

Recombinant Pig MIP-1 Beta
MBS225413-0005mg 0.005mg
EUR 355

Recombinant Pig MIP-1 Beta
MBS225413-5x0005mg 5x0.005mg
EUR 1435

Human recombinant MIP-1 beta
MI-300-3 10ug
EUR 200

Human recombinant MIP-1 beta
MI-300-4 50ug
EUR 800

Human recombinant MIP-2 beta
MI-320-3 10ug
EUR 200

Human recombinant MIP-2 beta
MI-320-4 50ug
EUR 800

rHu MIP-3-beta
AK8232-0005 5µg Ask for price

rHu MIP-3-beta
AK8232-0020 20µg Ask for price

rHu MIP-3-beta
AK8232-0100 100µg Ask for price

rHu MIP-3-beta
AK8232-1000 1mg Ask for price

MIP-1 beta Recombinant Protein
40-358-0002mg 0.002 mg
EUR 311.1
Description: Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1 alpha and MIP-1 beta are active on human and murine hematopoietic cells. Recombinant murine MIP-1 beta is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

MIP-1 beta Recombinant Protein
40-358-001mg 0.01 mg
EUR 437.1
Description: Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1 alpha and MIP-1 beta are active on human and murine hematopoietic cells. Recombinant murine MIP-1 beta is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

MIP-1 beta Recombinant Protein
40-365-0002mg 0.002 mg
EUR 311.1
Description: Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1 alpha and MIP-1 beta are active on human and murine hematopoietic cells. Recombinant human MIP-1 betais a 7.6 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

MIP-1 beta Recombinant Protein
40-365-001mg 0.01 mg
EUR 437.1
Description: Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1 alpha and MIP-1 beta are active on human and murine hematopoietic cells. Recombinant human MIP-1 betais a 7.6 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

MIP-1 beta Recombinant Protein
40-407-0005mg 0.005 mg
EUR 311.1
Description: Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1 alpha and MIP-1 beta are active on human and murine hematopoietic cells. Recombinant rat MIP-1 beta is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

MIP-1 beta Recombinant Protein
40-407-002mg 0.02 mg
EUR 437.1
Description: Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1 alpha and MIP-1 beta are active on human and murine hematopoietic cells. Recombinant rat MIP-1 beta is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

MIP-3-beta Antibody
abx235194-100g 100 µg
EUR 350

MIP-3-beta Antibody
abx235194-100ug 100 ug
EUR 577.2

CXCL2 (Gro beta, MIP-2)
MBS614445-01mg 0.1mg
EUR 840

CXCL2 (Gro beta, MIP-2)
MBS614445-5x01mg 5x0.1mg
EUR 3625

Anti-CCL19/Mip 3 Beta Rabbit Monoclonal Antibody
M01605 100ug/vial
EUR 154
Description: WB 1:500-1:2000

Anti-CCL19/Mip 3 Beta Rabbit Monoclonal Antibody
MBS179703-01mL 0.1mL
EUR 450

Anti-CCL19/Mip 3 Beta Rabbit Monoclonal Antibody
MBS179703-5x01mL 5x0.1mL
EUR 1870

Human CCL19/MIP-3 Beta ELISA Kit PicoKine®
EK0456 96 wells
EUR 499
Description: Human CCL19/MIP-3 Beta ELISA Kit PicoKine® (96 Tests). Quantitate Human CCL19 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Mouse CCL19/MIP-3 beta ELISA Kit PicoKine®
EK0457 96 wells
EUR 499
Description: Mouse CCL19/MIP-3 beta ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Ccl19 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Human MIP-3 Beta Flow Cytometry Assay - Group 6
HX87223 96 Tests
EUR 270

Rat Monoclonal anti-mouse CCL-19 (MIP-3 beta)
mAP-0171 100ug
EUR 250

Mouse Monoclonal anti-human CCL-19 (MIP-3 beta)
hAP-0143 100ug
EUR 250

Sheep Polyclonal anti-Human CCL-19 (MIP-3 beta)
hAP-5710 50ug
EUR 400

Mouse MIP-1 beta ELISA Kit
K0331252 96well
EUR 271
Description: https://komabiotech.co.kr/labiskoma/datasheet/K0331252.pdf

Human MIP-1 beta ELISA Kit
K0332139 96well
EUR 271

Mouse MIP-1 beta ELISA Kit
GWB-SKR096 96 Tests Ask for price

MIP-1 beta (human) ELISA Kit
K4785-100 100 assays
EUR 970.8
Description: Sensitive, Colorimetric Assay

Rabbit anti Pig MIP-1 Beta
MBS225020-01mg 0.1mg
EUR 645

Rabbit anti Pig MIP-1 Beta
MBS225020-5x01mg 5x0.1mg
EUR 2730

Rabbit anti Pig MIP-1 Beta
MBS225021-005mg 0.05mg
EUR 645

Rabbit anti Pig MIP-1 Beta
MBS225021-5x005mg 5x0.05mg
EUR 2730

Pig MIP-1 Beta (CCL4) Protein
abx670310-100g 100 µg
EUR 312.5

Pig MIP-1 Beta (CCL4) Protein
abx670310-5ug 5 ug
EUR 493.2

RABBIT ANTI HUMAN MIP-1 BETA
MBS221343-01mg 0.1mg
EUR 635

RABBIT ANTI HUMAN MIP-1 BETA
MBS221343-5x01mg 5x0.1mg
EUR 2695

MIP-1 beta, CCL4, murine (mouse)
RC335-15 2ug
EUR 125.26

Rabbit Anti Human Mip-3 Beta Polyclonal Antibody,Biotin
CPBT-65217RH 50 µg
EUR 659.4
Description: Rabbit

MIP-1 beta Rabbit mAb, capture
E2RB20113UC 100ul
EUR 485
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Anti-Mouse MIP-1 beta Antibody
103-P79 100 µg
EUR 245.7
Description: Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1α and MIP-1β exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant murine MIP-1β is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Anti-Human MIP-1 beta Antibody
102-P64 100 µg
EUR 245.7
Description: Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1α and MIP-1β exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant human MIP-1βis a 7.6 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines

Recombinant Human MIP-1 beta/CCL4
HECCP-0401 10ug Ask for price

Human MIP-1 beta (CCL4) Recombinant
MBS553044-0002mg 0.002mg
EUR 165

Human MIP-1 beta (CCL4) Recombinant
MBS553044-001mg 0.01mg
EUR 245

CXCL2 (Gro beta, MIP-2) (AP)
MBS6470975-01mL 0.1mL
EUR 1115

CXCL2 (Gro beta, MIP-2) (AP)
MBS6470975-5x01mL 5x0.1mL
EUR 4875

CXCL2 (Gro beta, MIP-2) (PE)
MBS6470996-01mL 0.1mL
EUR 1115

CXCL2 (Gro beta, MIP-2) (PE)
MBS6470996-5x01mL 5x0.1mL
EUR 4875

Rat MIP-1 beta Recombinant Protein
R20-035 20 µg
EUR 196.35
Description: Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1α and MIP-1β exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant rat MIP-1β is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Leave a Reply

Your email address will not be published.