thebarkerlab

Toll-interacting protein impacts on inflammation, autophagy

Posted on by Robert

Toll-interacting protein impacts on irritation, autophagy, and vacuole trafficking in human illness

Toll-interacting protein (TOLLIP) is a ubiquitous intracellular adaptor protein concerned in a number of intracellular signaling pathways. It performs a key position in mediating inflammatory intracellular responses, selling autophagy, and enabling vacuole transport throughout the cell. TOLLIP is being more and more acknowledged for its position in illness pathophysiology by way of involvement in these three main pathways. Current analysis additionally signifies that TOLLIP is concerned in nuclear-cytoplasmic switch, though this space requires additional exploration. TOLLIP is concerned within the pathophysiologic pathways related to neurodegenerative ailments, pulmonary ailments, heart problems, inflammatory bowel illness, and malignancy.

We postulate that TOLLIP performs an integral position within the illness pathophysiology of different situations concerned in vacuole trafficking and autophagy. We propose that future analysis on this discipline ought to examine the position of TOLLIP antibodies within the pathogenesis of those a number of situations.

This analysis has the potential to tell illness mechanisms and determine novel alternatives for therapeutic advances in a number of illness processes

Molecular docking-assisted screening reveals tannic acid as a pure protein disulphide isomerase inhibitor with antiplatelet and antithrombotic actions

Protein disulphide isomerase (PDI) promotes platelet activation and constitutes a novel antithrombotic goal. On this examine, we reported {that a} PDI-binding plant polyphenol, tannic acid (TA), inhibits PDI exercise, platelet activation and thrombus formation.

Molecular docking utilizing plant polyphenols from dietary sources with cardiovascular advantages revealed TA as probably the most potent binding molecule with PDI energetic centre. Floor plasmon resonance demonstrated that TA certain PDI with excessive affinity. Utilizing Di-eosin-glutathione disulphide fluorescence assay and PDI assay package, we confirmed that TA inhibited PDI exercise.

In remoted platelets, TA inhibited platelet aggregation stimulated by both GPVI or ITAM pathway agonists. Stream cytometry confirmed that TA inhibited thrombin- or CRP-stimulated platelet activation, as mirrored by diminished granule secretion and integrin activation. TA additionally diminished platelet spreading on immobilized fibrinogen and platelet adhesion below move situations.

In a laser-induced vascular harm mouse mannequin, intraperitoneal injection of TA considerably decreased the dimensions of cremaster arteriole thrombi. No prolongation of mouse jugular vein and tail-bleeding time was noticed after TA administration. Due to this fact, we recognized TA from pure polyphenols as a novel inhibitor of PDI perform. TA inhibits platelet activation and thrombus formation, suggesting it as a possible antithrombotic agent.

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Cellufine Sulfate
19846 500 ml
EUR 2892

Cellufine Sulfate
19847 5 lt Ask for price

Cellufine Sulfate
19849 10 lt Ask for price

Cellufine Formyl
21-855 5 lt Ask for price

Cellufine Formyl
20-854 500 ml
EUR 4075

Cellufine Sulfate
676-943-324 10 ml
EUR 302

Cellufine Formyl
676-944-324 10 ml
EUR 324

Cellufine Formyl
676-944-335 10 lt Ask for price

Cellufine PB
683-986-324 10 ml
EUR 452

Cellufine PB
683-986-326 50 ml Ask for price

Cellufine PB
683-986-328 500 ml Ask for price

Cellufine PB
683-986-330 5 lt Ask for price

Cellufine PB
683-986-335 10 lt Ask for price

Cellufine Phosphate
684-987-335 10 lt Ask for price

Cellufine Phosphate
685-987-330 5 lt Ask for price

MC Cellufine Sulfate
19-845-15 1 x 5 ml
EUR 366

MC Cellufine Sulfate
19-845-51 5 x 1 ml
EUR 366

MC Cellufine Phosphate
195-15 1 x 5 ml
EUR 430

MC Cellufine Phosphate
195-51 5 x 1 ml
EUR 430

Cellufine A-200
19611 500 ml
EUR 526

Cellufine A-200
19612 5 lt Ask for price

Cellufine GH-25
19711 500 ml
EUR 452

Cellufine GH-25
19712 5 lt Ask for price

Cellufine A-800
19800 500 ml
EUR 526

Cellufine A-800
19801 5 lt Ask for price

Cellufine A-500
19805 500 ml
EUR 526

Cellufine A-500
19806 5 lt Ask for price

Cellufine C-500
19865 500 ml
EUR 526

Cellufine C-500
19866 5 lt Ask for price

Cellufine Q-500
19907 500 ml
EUR 718

Cellufine Q-500
19908 5 lt Ask for price

Cellufine MAX DEAE
21-000 100 ml
EUR 382

Cellufine MAX DEAE
21-001 500 ml
EUR 1464

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21-002 5 lt Ask for price

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21-003 10 lt Ask for price

Cellufine MAX Butyl
21-100 100 ml
EUR 366

Cellufine MAX Butyl
21-101 500 ml
EUR 995

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21-102 5 lt Ask for price

Cellufine MAX Butyl
21-103 10 lt Ask for price

Cellufine S-500
21-200 100 ml
EUR 388

Cellufine S-500
21-201 500 ml
EUR 697

Cellufine S-500
21-202 5 lt Ask for price

Cellufine S-500
21-203 10 lt Ask for price

Cellufine MAX GS
21-300 100 ml
EUR 505

Cellufine MAX GS
21-301 500 ml
EUR 1635

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21-302 5 lt Ask for price

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21-303 10 lt Ask for price

Cellufine GCL-2000HF
21-400 100 ml
EUR 302

Cellufine GCL-2000HF
21-401 500 ml
EUR 452

Cellufine GCL-2000HF
21-402 5 lt Ask for price

Cellufine GCL-2000HF
21-403 10 lt Ask for price

Cellufine MAX AminoButyl
21-500 50 ml
EUR 375

Cellufine MAX AminoButyl
21-501 100 ml
EUR 622

Cellufine MAX AminoButyl
21-502 500 ml
EUR 2466

Cellufine MAX AminoButyl
21-503 5 lt Ask for price

Cellufine MAX AminoButyl
21-504 10 lt Ask for price

Cellufine MAX IB
21-600 10 ml
EUR 260

Cellufine MAX IB
21-601 50 ml
EUR 484

Cellufine MAX IB
21-602 100 ml
EUR 628

Cellufine MAX IB
21-603 500 ml
EUR 2402

Cellufine MAX IB
21-604 5 lt Ask for price

Cellufine MAX IB
21-605 10 lt Ask for price

Cellufine SPA-HC
21-900 10 ml
EUR 686

Cellufine SPA-HC
21-901 50 ml
EUR 1363

Cellufine SPA-HC
21-902 500 ml
EUR 6857

Cellufine SPA-HC
21-903 5 lt Ask for price

Cellufine SPA-HC
21-904 10 lt Ask for price

Cellufine MAX Phenyl
20700 100 ml
EUR 366

Cellufine MAX Phenyl
20701 500 ml
EUR 995

Cellufine MAX Phenyl
20702 5 lt Ask for price

Cellufine MAX Phenyl
20703 10 lt Ask for price

MC Cellufine PB
202-15 1 x 5 ml
EUR 452

MC Cellufine PB
202-51 5 x 1 ml
EUR 452

Cellufine GH-25
670000327 100 ml
EUR 302

Cellufine GH-25
670000335 10 lt Ask for price

Cellufine A-800
673980327 100 ml
EUR 324

Cellufine A-800
673980335 10 lt Ask for price

Cellufine A-500
675980327 100 ml
EUR 324

Cellufine A-500
675980335 10 lt Ask for price

Cellufine Q-500
675982327 100 ml
EUR 366

Cellufine Q-500
675982335 10 lt Ask for price

Cellufine C-500
675983327 100 ml
EUR 324

Cellufine C-500
675983335 10 lt Ask for price

Cellufine A-200
676-980-327 100 ml
EUR 324

Cellufine A-200
676980335 10 lt Ask for price

Cellufine ETclean L
681-984-324 10 ml
EUR 366

Cellufine ETclean L
681-984-326 50 ml
EUR 590

Cellufine ETclean L
681-984-328 500 ml
EUR 3020

Cellufine ETclean L
681-984-330 5 lt Ask for price

Cellufine ETclean L
681-984-335 10 lt Ask for price

Cellufine ETclean S
682-985-324 10 ml
EUR 366

Cellufine ETclean S
682-985-326 50 ml
EUR 590

Cellufine ETclean S
682-985-328 500 ml
EUR 3020

Cellufine ETclean S
682-985-330 5 lt Ask for price

Cellufine ETclean S
682-985-335 10 lt Ask for price

MC Cellufine A-200
19-611-51 5 x 1 ml
EUR 217

MC Cellufine GH-25
19-711-55 5 x 5 ml
EUR 430

MC Cellufine C-500
19-800-51 5 x 1 ml
EUR 217

MC Cellufine C-500
19-800-55 5 x 5 ml
EUR 345

MC Cellufine A-500
19-805-51 5 x 1 ml
EUR 217

MC Cellufine A-500
19-805-55 5 x 5 ml
EUR 345

MC Cellufine A-800
19-865-51 5 x 1 ml
EUR 217

MC Cellufine A-800
19-865-55 5 x 5 ml
EUR 345

MC Cellufine Q-500
19-907-51 5 x 1 ml
EUR 217

MC Cellufine Q-500
19-907-55 5 x 5 ml
EUR 345

MC Cellufine MAX DEAE
21-000-51 5 x 1 ml
EUR 271

MC Cellufine MAX DEAE
21-000-55 5 x 5 ml
EUR 526

MC Cellufine MAX Butyl
21-100-51 5 x 1 ml
EUR 271

MC Cellufine MAX Butyl
21-100-55 5 x 5 ml
EUR 537

MC Cellufine S-500
21-200-51 5 x 1 ml
EUR 239

MC Cellufine S-500
21-200-55 5 x 5 ml
EUR 420

MC Cellufine MAX GS
21-300-51 5 x 1 ml
EUR 271

MC Cellufine MAX GS
21-300-55 5 x 5 ml
EUR 526

MC Cellufine MAX AminoButyl
21-500-15 1 x 5 ml
EUR 451

MC Cellufine MAX AminoButyl
21-500-51 5 x 1 ml
EUR 451

MC Cellufine MAX IB
21-600-15 1 x 5 ml
EUR 302

MC Cellufine MAX IB
21-600-51 5 x 1 ml
EUR 302

Cellufine MAX DexS-Hbp
21-700 10 ml
EUR 260

Cellufine MAX DexS-Hbp
21-700-15 1 x 5 ml
EUR 302

Cellufine MAX DexS-Hbp
21-700-51 5 x 1 ml
EUR 302

Cellufine MAX DexS-Hbp
21-701 50 ml
EUR 484

Cellufine MAX DexS-Hbp
21-702 500 ml
EUR 2402

Cellufine MAX DexS-Hbp
21-704 10 lt Ask for price

Cellufine MAX DexS-Vir
21-800 10 ml
EUR 260

Cellufine MAX DexS-Vir
21-801 50 ml
EUR 484

Cellufine MAX DexS-Vir
21-802 500 ml
EUR 2402

Cellufine MAX DexS-Vir
21-804 10 lt Ask for price

MC Cellufine SPA-HC
21-900-11 1 x 1 ml
EUR 372

MC Cellufine SPA-HC
21-900-15 1 x 5 ml
EUR 553

MC Cellufine SPA-HC
21-900-51 5 x 1 ml
EUR 553

Cellufine MAX DexS-Hbp
21703 5 lt Ask for price

Cellufine MAX DexS-Vir
21803 5 lt Ask for price

Cellufine MAX Phenyl LS
20800 100 ml
EUR 366

Cellufine MAX Phenyl LS
20801 500 ml
EUR 995

Cellufine MAX Phenyl LS
20802 5 lt Ask for price

Cellufine MAX Phenyl LS
20803 10 lt Ask for price

Cellufine MAX S-r
20-300 100 ml
EUR 382

Cellufine MAX S-r
20-301 500 ml
EUR 1464

Cellufine MAX S-r
20-302 5 lt Ask for price

Cellufine MAX S-r
20-303 10 lt Ask for price

Cellufine MAX S-h
20-400 100 ml
EUR 382

Cellufine MAX S-h
20-401 500 ml
EUR 1464

Cellufine MAX S-h
20-402 5 lt Ask for price

Cellufine MAX S-h
20-403 10 lt Ask for price

The newest developments in imaging fibroblast activation protein (FAP)

Fibroblast activation protein (FAP), a membrane-anchored peptidase, is extremely expressed in cancer-associated fibroblasts (CAFs) in additional than 90% of epithelial tumors and contributes to development and worse prognosis of various cancers. Due to this fact, FAP is taken into account a promising goal for radionuclide-based approaches for analysis and therapy of tumors and for the analysis of non-malignant ailments related to a reworking of the extracellular matrix.
Accordingly, a wide range of quinolone-based FAP inhibitors (FAPI) coupled to chelators had been developed displaying particular binding to human and murine FAP with a speedy and nearly full internalization. On account of a excessive tumor uptake and a really low accumulation in regular tissues in addition to a speedy clearance from the circulation, a high-contrast is obtained for FAPI-PET/CT imaging even at 10 minutes after tracer administration.
Furthermore, FAPI-PET/CT gives benefits over FDG-PET/CT in a number of tumor entities for preliminary staging and detection of tumor recurrence and metastases together with peritonitis carcinomatosa.

Autoimmunity linked protein phosphatase PTPN22 as a goal for most cancers immunotherapy

Background: Most cancers immunotherapy has advanced from interferon-alpha (IFNα) and interleukin-2 within the 1980s to CTLA-Four and PD-1/PD-L1 checkpoint inhibitors (CPIs), the latter highlighting the significance of enhancing T-cell features.
Whereas the seek for novel immunomodulatory pathways continues, mixture therapies augmenting a number of pathways may enhance efficacy. The affiliation of autoimmune-related antagonistic occasions with medical efficacy following CPI therapy has been inferred and means that breaking tolerance thresholds related to autoimmunity might have an effect on host immune responses for efficient most cancers immunotherapy.
Outcomes: Right here, we present that lack of autoimmune related PTPN22, a key desensitization node for a number of signaling pathways, together with IFNα receptor (IFNAR) and T-cell receptor, can increase tumor responses. Implantation of syngeneic tumors in Ptpn22-/- mice led to growth and activation of peripheral and intratumoral T cells and, in flip, spontaneous tumor regression in addition to enhanced responses together with anti-PD-L1 therapy.
Utilizing genetically modified mice expressing a catalytically inactive PTPN22 or the autoimmunity-associated human single-nucleotide polymorphism variant, augmentation of antitumor immunity was depending on PTPN22 phosphatase exercise and partially on its adaptor features.
Additional, antitumor responses had been depending on each CD4+ and CD8+T cells and, partly, IFNAR perform. Lastly, we reveal that the autoimmune susceptibility Ptpn22(C1858T) variant is related to decrease danger of creating non-melanoma pores and skin cancers, improved general survival and elevated danger for growth of hyperthyroidism or hypothyroidism following atezolizumab (anti-PD-L1) therapy.
Conclusions: Collectively, these knowledge recommend that inhibition of PTPN22 phosphatase exercise might present an efficient therapeutic possibility for most cancers immunotherapy and that exploring genetic variants that shift immune tolerance thresholds might function a paradigm for locating new most cancers immunotherapy targets.

Recombinant Proteins Co-Expressed and Co-Purified within the Presence of Antibody Fragments

Recombinant antibodies in single-domain format (VHHs) have been lately used for stabilizing antigens throughout their purification and crystallization. VHHs are additionally recognized for his or her structural stability and a big a part of them share the attribute of remaining functionally folded additionally within the absence of the interior disulfide bond.
Due to this fact, they are often expressed as intrabodies within the cell cytoplasm in addition to within the bacterial periplasm. This proof implies that, in idea, VHHs may be co-expressed with their antigens independently on the redox constrains.
It has additionally urged the concept of utilizing co-expression and co-purification of antigen-antibody complexes for maximizing the stabilizing impact of the antibody on its antigen throughout all of the manufacturing steps for each cytoplasmic and periplasmic expression methods.

An Orthogonal Fusion Tag for Environment friendly Protein Purification

On this chapter, we current an environment friendly methodology for stringent protein purification facilitated by a twin affinity tag known as ABDz1, which is predicated on a 5 kDa albumin-binding area from Streptococcal Protein G. The small fusion tag allows an orthogonal affinity purification method based mostly on two successive and extremely particular affinity purification steps.
This method is enabled by native binding of ABDz1 to human serum albumin and engineered binding to Staphylococcal Protein A, respectively. The ABDz1-tag may be fused to both terminus of a protein of curiosity and the purification steps may be carried out utilizing commonplace laboratory gear.

MIP-3-beta Antibody
abx235194-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.

anti- MIP-3-beta antibody
FNab05194 100µg
EUR 505.25
  • Immunogen: chemokine(C-C motif) ligand 19
  • Uniprot ID: Q99731
  • Research Area: Immunology, Signal Transduction
Description: Antibody raised against MIP-3-beta

MIP-3-beta/CCL19, Mouse
HY-P7264 50ug
EUR 533

Anti-MIP-3-beta antibody
PAab05194 100 ug
EUR 355

MIP-3 beta, CCL19, murine (mouse)
RC335-20 5ug
EUR 101.33
  • Product category: Proteins/Recombinant Proteins/Cytokines

rHu MIP-1-beta
AK8264-0002 2µg Ask for price

rHu MIP-1-beta
AK8264-0010 10µg Ask for price

rHu MIP-1-beta
AK8264-0100 100µg Ask for price

rHu MIP-1-beta
AK8264-1000 1mg Ask for price

MIP-1-beta Antibody
5249-100
EUR 338

MIP 1 beta antibody
20R-1789 100 ug
EUR 673
Description: Rabbit polyclonal MIP 1 beta antibody

Anti-MIP- beta antibody
STJ94131 200 µl
EUR 197
Description: Rabbit polyclonal to MIP-3beta.

Anti-MIP- beta antibody
STJ96572 200 µl
EUR 197
Description: Rabbit polyclonal to MIP-1beta.

rM IL-2
AK8323-0005 5µg Ask for price

rM IL-2
AK8323-0020 20µg Ask for price

rM IL-2
AK8323-0100 100µg Ask for price

rM IL-2
AK8323-1000 1mg Ask for price

Recombinant Murine MIP-3 Beta (CCL19) Protein
PROTO70460-2 20ug
EUR 317
Description: MIP-3β is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3β is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3β is active on murine cells. Recombinant murine MIP-3β is a 9.2 kDa protein containing 83 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Human CCL19/MIP-3 beta ELISA Kit
LF-EK50840 1×96T
EUR 648

Recombinant Human MIP-3 Beta (CCL19) Protein
PROTQ99731-1 20ug
EUR 317
Description: MIP-3β is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3β is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3β is active on murine cells. Recombinant human MIP-3β is an 8.8 kDa protein containing 77 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

MIP-3
EF016652 96 Tests
EUR 689

MIP-3
EF016984 96 Tests
EUR 689

MIP-3
EF017888 96 Tests
EUR 689

MIP-3
EF012726 96 Tests
EUR 689

MIP-3
EF013760 96 Tests
EUR 689

MIP-3
EF013761 96 Tests
EUR 689

MIP-3
EF010865 96 Tests
EUR 689

MIP-3
PAab09791 100 ug
EUR 386

Anti-14-3-3 alpha + beta Rabbit Monoclonal Antibody
M02431-3 100ug/vial
EUR 397
Description: Rabbit Monoclonal 14-3-3 alpha + beta Antibody. Validated in Flow Cytometry, IP, IF, IHC, ICC, WB and tested in Human, Mouse, Rat.

1 mm Gaskets 3/pk, RM
2398237 5unit
EUR 257

MIP-1-beta/CCL4, Human
HY-P7257 10ug
EUR 268

MIP-1 beta, CCL4, human
RC314-15 2ug
EUR 101.33
  • Product category: Proteins/Recombinant Proteins/Cytokines

MIP-1 beta, CCL4, rat
RC355-15 5ug
EUR 104.38
  • Product category: Proteins/Recombinant Proteins/Cytokines

ELISA kit for Human CCL19/MIP-3 Beta
EK5194 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Human CCL19/MIP-3 Beta in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Mouse CCL19/MIP-3 beta
EK5195 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse CCL19/MIP-3 beta in samples from serum, plasma, tissue homogenates and other biological fluids.

Human CCL19/MIP-3 beta PicoKine ELISA Kit
EK0456 96 wells
EUR 425
Description: For quantitative detection of human CCL19 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Mouse CCL19/MIP-3 beta PicoKine ELISA Kit
EK0457 96 wells
EUR 425
Description: For quantitative detection of mouse CCL19 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Rabbit Anti Human Mip-3 Beta Polyclonal Antibody
CPBT-65218RH 0.1 mg
EUR 881

Anti-CCL19/Mip 3 Beta Rabbit Monoclonal Antibody
M01605 100ug/vial
EUR 397
Description: Rabbit Monoclonal CCL19/Mip 3 Beta Antibody. Validated in WB and tested in Human.

Clips 4/pk RM
2398239 6unit
EUR 250

1mm Pressure Platen - RM
2398242 3unit
EUR 281

TGF-b-3 Transforming Growth Factor-Beta 3 Human Recombinant Protein, Plant
PROTP10600-3 Regular: 5ug
EUR 317
Description: TGFB3 Human Recombinant produced in plant is a disulfide-linked homodimeric, glycosylated, polypeptide chain containing 118 amino acids and having a molecular mass of 27.2kDa. ;The TGFB3 is fused to 6xHis tag at N-terminus and purified by standard chromatographic techniques.

anti- MIP-3
LSMab09791 100 ug
EUR 386

Pig MIP-1 Beta (CCL4) Protein
abx670310-5ug 5 ug
EUR 411
  • Shipped within 1 week.

GRO beta / MIP-2 (CXCL2) Protein
20-abx261572
  • EUR 328.00
  • EUR 3418.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.

GRO beta / MIP-2 (CXCL2) Protein
20-abx261590
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.

GRO beta / MIP-2 (CXCL2) Protein
20-abx261604
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.

MIP-2/Gro-beta, murine recombinant
4251-1000
EUR 5204

MIP-2/Gro-beta, murine recombinant
4251-20
EUR 297

GRO-beta/MIP-2, rat recombinant
4108-1000
EUR 3965

GRO-beta/MIP-2, rat recombinant
4108-20
EUR 262

MIP-1 beta (human) ELISA Kit
K4785-100 100 assays
EUR 809
  • Kit components:
  • MIP-1 β antibody-coated Microplate (Item A), 96 wells
  • Wash Buffer (20x) (Item B)
  • rh MIP-1 β Standards (Item C)
  • Assay Diluent A (Item D)
  • Assay Diluent B (5x) (Item E)
  • MIP-1 β Detection Antibody (Item F)
  • HRP-St
  • Show more
Description: Sensitive, Colorimetric Assay

MIP-1 beta, CCL4, murine (mouse)
RC335-15 2ug
EUR 104.38
  • Product category: Proteins/Recombinant Proteins/Cytokines

Rabbit Anti Human Mip-3 Beta Polyclonal Antibody,Biotin
CPBT-65217RH 50 µg
EUR 881

Anti-IL1 beta Antibody
A00101-3 100ug
EUR 455
Description: Rabbit Polyclonal IL1 beta Antibody. Validated in IP, IF, IHC, WB and tested in Mouse, Rat.

1 mm Preparative Comb, RM
2328934 3unit
EUR 253
Description: 1 sampl e wel l and 1 r efer ence wel l

0.75mm Plate Set,RM-075
2393014 2unit
EUR 263
Description: 1 pai r of gl ass pl at es + 1 gask et , for 0.75 mm gel

5 mm Dummy Plate, RM
2393074 10unit
EUR 241
Description: Pl ast i c pl at e for r unni ng 1 Pagel pr ecast gel onl y

2mm Plate Set,RM-22
2393740 3unit
EUR 281
Description: 1 pai r of gl ass pl at es + 1 gask et , for 2 mm gel

7 mm Dummy Plate, RM
2398247 10unit
EUR 241
Description: Pl ast i c pl at e for r unni ng 1 hand-cast gel onl y

1 mm Blank Comb, RM
2399041 4unit
EUR 272

Anti-GLB1/Beta-galactosidase Antibody
A01829-3 100ug/vial
EUR 334

Recombinant Human IFN-Beta Protein
PROTP01574-3 20ug
EUR 317
Description: Proteins of this family play an important role in inducing non-specific resistance against a broad range of viral infections. They also affect cell proliferation and modulate immune responses. Produced by peripheral blood leukocytes and lymphoblastoid cells, IFNα is an acid stable molecule that signals through IFNα/βR, which is also used by IFNβ. Both IFNs have similar anti-viral activity and regulate expression of MHC class I antigens. IFNα contains four highly conserved cysteine residues which form two disulfide bonds, one of which is necessary for biological activity. Recombinant human IFNβ is an 20.0 kDa protein containing 166 amino acid residues. Due to glycosylation, IFNβ has an approximate MW of 22.3 kDa based on SDS-PAGE gel and Mass Spectrometry.

*Human IFN-β(Catalog Number 300-02BC) has replaced Human IFN-β(Catalog Number 300-02B)

Anti- Beta-tubulin Monoclonal Antibody
M05613-3 100ul
EUR 397
Description: Mouse Monoclonal Beta-tubulin Antibody. Validated in IHC, WB and tested in Human, Monkey, Mouse, Rat.

Swine IFN beta Recombinant Protein
R02041-3 5ug/vial
EUR 259
Description: IFN beta is a mammalian Type I interferon, functioning as a regulator of cellular activity by interacting with cell-surface receptors and activating various signaling pathways. IFN beta produces antiviral, antibacterial, and anticancer properties. Swine IFN beta Recombinant Protein is purified IFN beta produced in yeast.

GRO beta / MIP-2 (CXCL2) His Protein
20-abx260689
  • EUR 328.00
  • EUR 3418.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.

Recombinant Human GRO-beta/MIP-2 (CXCL2)
7-01864 2µg Ask for price

Recombinant Human GRO-beta/MIP-2 (CXCL2)
7-01865 10µg Ask for price

Recombinant Human GRO-beta/MIP-2 (CXCL2)
7-01866 1mg Ask for price

Recombinant Mouse GRO-beta/MIP-2 (CXCL2)
7-01870 5µg Ask for price

Recombinant Mouse GRO-beta/MIP-2 (CXCL2)
7-01871 20µg Ask for price

Recombinant Mouse GRO-beta/MIP-2 (CXCL2)
7-01872 1mg Ask for price

Recombinant Rat GRO-beta/MIP-2 (CXCL2)
7-01873 5µg Ask for price

Recombinant Rat GRO-beta/MIP-2 (CXCL2)
7-01874 20µg Ask for price

Recombinant Rat GRO-beta/MIP-2 (CXCL2)
7-01875 1mg Ask for price

Recombinant Murine MIP-1 Beta (CCL4) Protein
PROTP14097-1 10ug
EUR 317
Description: Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1α and MIP-1β exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant murine MIP-1β is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Human CCL4/MIP-1 beta ELISA Kit
LF-EK50838 1×96T
EUR 648

Rat CCL4/MIP-1 beta ELISA Kit
LF-EK50964 1×96T
EUR 648

Mouse MIP-1-beta/CCL4 ELISA Kit
RK00072 96 Tests
EUR 521

Human MIP-1-beta/CCL4 ELISA Kit
RK00138 96 Tests
EUR 521

Recombinant Rat MIP-1 Beta (CCL4) Protein
PROTP50230-1 20ug
EUR 317
Description: Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1α and MIP-1β exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant rat MIP-1β is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Recombinant Human MIP-1 Beta (CCL4) Protein
PROTQ8NHW4-2 10ug
EUR 317
Description: Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1α and MIP-1β exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant human MIP-1βis a 7.6 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Recombinant Human MIP-3 beta/ CCL19 Protein, GST, E.coli-100ug
QP8024-ec-100ug 100ug
EUR 408

Recombinant Human MIP-3 beta/ CCL19 Protein, GST, E.coli-10ug
QP8024-ec-10ug 10ug
EUR 200

Recombinant Human MIP-3 beta/ CCL19 Protein, GST, E.coli-1mg
QP8024-ec-1mg 1mg
EUR 1632

Recombinant Human MIP-3 beta/ CCL19 Protein, GST, E.coli-200ug
QP8024-ec-200ug 200ug
EUR 634

Recombinant Human MIP-3 beta/ CCL19 Protein, GST, E.coli-500ug
QP8024-ec-500ug 500ug
EUR 1060

Recombinant Human MIP-3 beta/ CCL19 Protein, GST, E.coli-50ug
QP8024-ec-50ug 50ug
EUR 263

Recombinant Mouse MIP-3 beta/ CCL19 Protein, Untagged, E.coli-100ug
QP10273-ec-100ug 100ug
EUR 988

Recombinant Mouse MIP-3 beta/ CCL19 Protein, Untagged, E.coli-20ug
QP10273-ec-20ug 20ug
EUR 290

Recombinant Mouse MIP-3 beta/ CCL19 Protein, Untagged, E.coli-250ug
QP10273-ec-250ug 250ug
EUR 1731

Recombinant Mouse MIP-3 beta/ CCL19 Protein, Untagged, E.coli-5ug
QP10273-ec-5ug 5ug
EUR 154

Recombinant Mouse MIP-3 beta/ CCL19 Protein, Untagged, E.coli-1mg
QP5219-1mg 1mg
EUR 2856

Recombinant Mouse MIP-3 beta/ CCL19 Protein, Untagged, E.coli-500ug
QP5219-500ug 500ug
EUR 1778

Recombinant Human MIP-3 beta/ CCL19 Protein, Untagged, E.coli-100ug
QP5258-100ug 100ug
EUR 490

Recombinant Human MIP-3 beta/ CCL19 Protein, Untagged, E.coli-1mg
QP5258-1mg 1mg
EUR 2856

Recombinant Human MIP-3 beta/ CCL19 Protein, Untagged, E.coli-20ug
QP5258-20ug 20ug
EUR 237

Recombinant Human MIP-3 beta/ CCL19 Protein, Untagged, E.coli-500ug
QP5258-500ug 500ug
EUR 1778

Recombinant Human MIP-3 beta/ CCL19 Protein, Untagged, E.coli-5ug
QP5258-5ug 5ug
EUR 136

rHu MIP-3-alpha
AK8271-0005 5µg Ask for price

rHu MIP-3-alpha
AK8271-0020 20µg Ask for price

rHu MIP-3-alpha
AK8271-0100 100µg Ask for price

rHu MIP-3-alpha
AK8271-1000 1mg Ask for price

MIP-3? Polyclonal Antibody
ES7130-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against MIP-3? from Human. This antibody is tested and validated for IHC, WB, ELISA

MIP-3? Polyclonal Antibody
ES7130-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against MIP-3? from Human. This antibody is tested and validated for IHC, WB, ELISA

MIP-3? Polyclonal Antibody
ES8712-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against MIP-3? from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA

MIP-3? Polyclonal Antibody
ES8712-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against MIP-3? from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA

MIP-3, CCL23, human
RC315-34 5ug
EUR 104.38
  • Product category: Proteins/Recombinant Proteins/Cytokines

Anti-beta 2 Microglobulin/B2m Antibody
A00456-3 100ug/vial
EUR 294

Recombinant Human IL-1 Beta Protein
PROTP01584-3 10ug
EUR 317
Description: IL-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant human IL-1β is a 17.3 kDa protein containing 153 amino acid residues.

Anti-Beta Tubulin Antibody (monoclonal, 5E4)
M01857-3 100ug/vial
EUR 294

Equine IL-1 beta Recombinant Protein
R00101-3 5ug/vial
EUR 259
Description: IL-1 beta (IL-1β) is a member of the interleukin 1 family of cytokines. The IL-1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. Equine IL-1 beta Recombinant Protein is purified interleukin-1 beta cytokine produced in yeast.

Recombinant Human TNF-Beta (E.coli-derived) Protein
PROTP01374-3 20ug
EUR 317
Description: TNF-β is a potent mediator of inflammatory and immune responses. It belongs to the TNF family of ligands and signals through TNFR1 and TNFR2. TNF-β is produced by activated T and B lymphocytes, and has similar activities to TNF-α. Like TNF-α, TNF-β is involved in the regulation of various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNF-β is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-β, which effectively anchors the TNF-β to the cell surface. TNF-β is cytotoxic to a wide range of tumor cells. Recombinant human TNF-β is a secreted 171 amino acid protein (18.6 kDa) which forms an active non-disulfide linked homotrimer structure in solution.

Mip/ Rat Mip ELISA Kit
ELI-23038r 96 Tests
EUR 886

1 mm 6-well Comb, RM
2328375 3unit
EUR 255

1 mm 8-well Comb, RM
2328376 3unit
EUR 255

1 mm 20-well Comb, RM
2328422 3unit
EUR 311

1 mm 10-well Comb, RM
2328948 3unit
EUR 288

A-M310 agarGEL RM, 10/pk
2332200 2unit
EUR 351
Description: pH 3 - 10

A-M38 agarGEL RM, 10/pk
2332210 2unit
EUR 351
Description: pH 3 - 8

A-M58 agarGEL RM, 10/pk
2332220 2unit
EUR 351
Description: pH 5 - 8

A-M510 agarGEL RM, 10/pk
2332230 2unit
EUR 351
Description: pH 5 - 10

1 mm Plate Set, RM-10
2398214 3unit
EUR 281
Description: 1 pai r of gl ass pl at es + 1 gask et , for 1 mm gel

0.75mm Glass plates 2/pk,RM
2398228 2unit
EUR 279
Description: N ot ched pl at e wi t h 0.75mm si de-spacer s

2mm Glass plates 2/pk, RM
2398236 2unit
EUR 249
Description: N ot ched pl at e wi t h 2mm si de-spacer s

0.75mm 12-well Combs 2pk,RM
2398271 2unit
EUR 269

Recombinant Human TGF-Beta 2 (mammalian derived) Protein
PROTP61812-3 10ug
EUR 317
Description: The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development. Recombinant human TGF-β2 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.

MIP-3b Macrophage Inflammatory Protein-3 Beta Mouse Recombinant Protein (CCL19)
PROTO70460 Regular: 20ug
EUR 317
Description: Macrophage Inflammatory Protein-3 beta Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 83 amino acids and having a molecular mass of 9216 Dalton. ;The MIP-3b is purified by proprietary chromatographic techniques.

MIP-3b Macrophage Inflammatory Protein-3 Beta Human Recombinant Protein (CCL19)
PROTQ99731 Regular: 20ug
EUR 317
Description: Macrophage Inflammatory Protein-3 beta Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 77 amino acids and having a molecular mass of 8.8kDa. ;The MIP-3b is purified by proprietary chromatographic techniques.

ELISA kit for Human CCL4/MIP-1 Beta
EK5189 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Human CCL4/MIP-1 Beta in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Rat CCL4/MIP-1 Beta
EK5423 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Rat CCL4/MIP-1 Beta in samples from serum, plasma, tissue homogenates and other biological fluids.

Human CCL4/MIP-1 beta PicoKine ELISA Kit
EK0450 96 wells
EUR 425
Description: For quantitative detection of human CCL4 in cell culture supernates, serum and plasma(heparin, EDTA, citrate).

Rat CCL4/MIP-1 beta PicoKine ELISA Kit
EK0939 96 wells
EUR 425
Description: For quantitative detection of rat CCL4 in cell culture supernates, serum and plasma(heparin, EDTA, citrate).

Rabbit Anti Human Mip-1 Beta Polyclonal Antibody
CPBT-65212RH 0.1 mg
EUR 881

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