Toll-interacting protein impacts on irritation, autophagy, and vacuole trafficking in human illness
Toll-interacting protein (TOLLIP) is a ubiquitous intracellular adaptor protein concerned in a number of intracellular signaling pathways. It performs a key position in mediating inflammatory intracellular responses, selling autophagy, and enabling vacuole transport throughout the cell. TOLLIP is being more and more acknowledged for its position in illness pathophysiology by way of involvement in these three main pathways. Current analysis additionally signifies that TOLLIP is concerned in nuclear-cytoplasmic switch, though this space requires additional exploration. TOLLIP is concerned within the pathophysiologic pathways related to neurodegenerative ailments, pulmonary ailments, heart problems, inflammatory bowel illness, and malignancy.
We postulate that TOLLIP performs an integral position within the illness pathophysiology of different situations concerned in vacuole trafficking and autophagy. We propose that future analysis on this discipline ought to examine the position of TOLLIP antibodies within the pathogenesis of those a number of situations.
This analysis has the potential to tell illness mechanisms and determine novel alternatives for therapeutic advances in a number of illness processes
Molecular docking-assisted screening reveals tannic acid as a pure protein disulphide isomerase inhibitor with antiplatelet and antithrombotic actions
Protein disulphide isomerase (PDI) promotes platelet activation and constitutes a novel antithrombotic goal. On this examine, we reported {that a} PDI-binding plant polyphenol, tannic acid (TA), inhibits PDI exercise, platelet activation and thrombus formation.
Molecular docking utilizing plant polyphenols from dietary sources with cardiovascular advantages revealed TA as probably the most potent binding molecule with PDI energetic centre. Floor plasmon resonance demonstrated that TA certain PDI with excessive affinity. Utilizing Di-eosin-glutathione disulphide fluorescence assay and PDI assay package, we confirmed that TA inhibited PDI exercise.
In remoted platelets, TA inhibited platelet aggregation stimulated by both GPVI or ITAM pathway agonists. Stream cytometry confirmed that TA inhibited thrombin- or CRP-stimulated platelet activation, as mirrored by diminished granule secretion and integrin activation. TA additionally diminished platelet spreading on immobilized fibrinogen and platelet adhesion below move situations.
In a laser-induced vascular harm mouse mannequin, intraperitoneal injection of TA considerably decreased the dimensions of cremaster arteriole thrombi. No prolongation of mouse jugular vein and tail-bleeding time was noticed after TA administration. Due to this fact, we recognized TA from pure polyphenols as a novel inhibitor of PDI perform. TA inhibits platelet activation and thrombus formation, suggesting it as a possible antithrombotic agent.
Cellufine Sulfate |
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| 676-943-324 | JNC America | 10 ml | EUR 302 |
Cellufine Formyl |
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| 676-944-324 | JNC America | 10 ml | EUR 324 |
Cellufine Formyl |
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| 676-944-335 | JNC America | 10 lt | Ask for price |
Cellufine PB |
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| 683-986-324 | JNC America | 10 ml | EUR 452 |
Cellufine PB |
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| 683-986-326 | JNC America | 50 ml | Ask for price |
Cellufine PB |
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| 683-986-328 | JNC America | 500 ml | Ask for price |
Cellufine PB |
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| 683-986-330 | JNC America | 5 lt | Ask for price |
Cellufine PB |
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| 683-986-335 | JNC America | 10 lt | Ask for price |
Cellufine Phosphate |
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| 684-987-335 | JNC America | 10 lt | Ask for price |
Cellufine Phosphate |
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| 685-987-330 | JNC America | 5 lt | Ask for price |
MC Cellufine Sulfate |
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| 19-845-15 | JNC America | 1 x 5 ml | EUR 366 |
MC Cellufine Sulfate |
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| 19-845-51 | JNC America | 5 x 1 ml | EUR 366 |
MC Cellufine Phosphate |
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| 195-15 | JNC America | 1 x 5 ml | EUR 430 |
MC Cellufine Phosphate |
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| 195-51 | JNC America | 5 x 1 ml | EUR 430 |
Cellufine A-200 |
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| 19611 | JNC America | 500 ml | EUR 526 |
Cellufine A-200 |
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| 19612 | JNC America | 5 lt | Ask for price |
Cellufine GH-25 |
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| 19711 | JNC America | 500 ml | EUR 452 |
Cellufine GH-25 |
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| 19712 | JNC America | 5 lt | Ask for price |
Cellufine A-800 |
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| 19800 | JNC America | 500 ml | EUR 526 |
Cellufine A-800 |
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| 19801 | JNC America | 5 lt | Ask for price |
Cellufine A-500 |
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| 19805 | JNC America | 500 ml | EUR 526 |
Cellufine A-500 |
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| 19806 | JNC America | 5 lt | Ask for price |
Cellufine C-500 |
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| 19865 | JNC America | 500 ml | EUR 526 |
Cellufine C-500 |
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| 19866 | JNC America | 5 lt | Ask for price |
Cellufine Q-500 |
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| 19907 | JNC America | 500 ml | EUR 718 |
Cellufine Q-500 |
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| 19908 | JNC America | 5 lt | Ask for price |
MC Cellufine PB |
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| 202-15 | JNC America | 1 x 5 ml | EUR 452 |
MC Cellufine PB |
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| 202-51 | JNC America | 5 x 1 ml | EUR 452 |
Cellufine MAX Phenyl |
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| 20700 | JNC America | 100 ml | EUR 366 |
Cellufine MAX Phenyl |
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| 20701 | JNC America | 500 ml | EUR 995 |
Cellufine MAX Phenyl |
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| 20702 | JNC America | 5 lt | Ask for price |
Cellufine MAX Phenyl |
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| 20703 | JNC America | 10 lt | Ask for price |
Cellufine MAX DEAE |
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| 21-000 | JNC America | 100 ml | EUR 382 |
Cellufine MAX DEAE |
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| 21-001 | JNC America | 500 ml | EUR 1464 |
Cellufine MAX DEAE |
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| 21-002 | JNC America | 5 lt | Ask for price |
Cellufine MAX DEAE |
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| 21-003 | JNC America | 10 lt | Ask for price |
Cellufine MAX Butyl |
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| 21-100 | JNC America | 100 ml | EUR 366 |
Cellufine S-500 |
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| 21-200 | JNC America | 100 ml | EUR 388 |
Cellufine S-500 |
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| 21-201 | JNC America | 500 ml | EUR 697 |
Cellufine S-500 |
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| 21-202 | JNC America | 5 lt | Ask for price |
Cellufine S-500 |
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| 21-203 | JNC America | 10 lt | Ask for price |
Cellufine MAX GS |
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| 21-300 | JNC America | 100 ml | EUR 505 |
Cellufine MAX GS |
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| 21-303 | JNC America | 10 lt | Ask for price |
Cellufine GCL-2000HF |
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| 21-400 | JNC America | 100 ml | EUR 302 |
Cellufine GCL-2000HF |
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| 21-401 | JNC America | 500 ml | EUR 452 |
Cellufine GCL-2000HF |
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| 21-402 | JNC America | 5 lt | Ask for price |
Cellufine GCL-2000HF |
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| 21-403 | JNC America | 10 lt | Ask for price |
Cellufine MAX AminoButyl |
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| 21-500 | JNC America | 50 ml | EUR 375 |
Cellufine MAX AminoButyl |
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| 21-501 | JNC America | 100 ml | EUR 622 |
Cellufine MAX AminoButyl |
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| 21-502 | JNC America | 500 ml | EUR 2466 |
Cellufine MAX AminoButyl |
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| 21-503 | JNC America | 5 lt | Ask for price |
Cellufine MAX AminoButyl |
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| 21-504 | JNC America | 10 lt | Ask for price |
Cellufine MAX IB |
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| 21-600 | JNC America | 10 ml | EUR 260 |
Cellufine MAX IB |
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| 21-601 | JNC America | 50 ml | EUR 484 |
Cellufine MAX IB |
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| 21-602 | JNC America | 100 ml | EUR 628 |
Cellufine MAX IB |
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| 21-603 | JNC America | 500 ml | EUR 2402 |
Cellufine MAX IB |
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| 21-604 | JNC America | 5 lt | Ask for price |
Cellufine MAX IB |
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| 21-605 | JNC America | 10 lt | Ask for price |
Cellufine SPA-HC |
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| 21-900 | JNC America | 10 ml | EUR 686 |
Cellufine SPA-HC |
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| 21-901 | JNC America | 50 ml | EUR 1363 |
Cellufine SPA-HC |
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| 21-902 | JNC America | 500 ml | EUR 6857 |
Cellufine SPA-HC |
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| 21-903 | JNC America | 5 lt | Ask for price |
Cellufine SPA-HC |
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| 21-904 | JNC America | 10 lt | Ask for price |
Cellufine GH-25 |
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| 670000327 | JNC America | 100 ml | EUR 302 |
Cellufine GH-25 |
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| 670000335 | JNC America | 10 lt | Ask for price |
Cellufine A-800 |
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| 673980327 | JNC America | 100 ml | EUR 324 |
Cellufine A-800 |
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| 673980335 | JNC America | 10 lt | Ask for price |
Cellufine A-500 |
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| 675980327 | JNC America | 100 ml | EUR 324 |
Cellufine A-500 |
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| 675980335 | JNC America | 10 lt | Ask for price |
Cellufine Q-500 |
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| 675982327 | JNC America | 100 ml | EUR 366 |
Cellufine Q-500 |
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| 675982335 | JNC America | 10 lt | Ask for price |
Cellufine C-500 |
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| 675983327 | JNC America | 100 ml | EUR 324 |
Cellufine C-500 |
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| 675983335 | JNC America | 10 lt | Ask for price |
Cellufine A-200 |
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| 676-980-327 | JNC America | 100 ml | EUR 324 |
Cellufine A-200 |
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| 676980335 | JNC America | 10 lt | Ask for price |
Cellufine ETclean L |
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| 681-984-324 | JNC America | 10 ml | EUR 366 |
Cellufine ETclean L |
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| 681-984-326 | JNC America | 50 ml | EUR 590 |
Cellufine ETclean L |
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| 681-984-328 | JNC America | 500 ml | EUR 3020 |
Cellufine ETclean L |
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| 681-984-330 | JNC America | 5 lt | Ask for price |
Cellufine ETclean L |
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| 681-984-335 | JNC America | 10 lt | Ask for price |
Cellufine ETclean S |
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| 682-985-324 | JNC America | 10 ml | EUR 366 |
Cellufine ETclean S |
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| 682-985-326 | JNC America | 50 ml | EUR 590 |
Cellufine ETclean S |
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| 682-985-328 | JNC America | 500 ml | EUR 3020 |
Cellufine ETclean S |
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| 682-985-330 | JNC America | 5 lt | Ask for price |
Cellufine ETclean S |
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| 682-985-335 | JNC America | 10 lt | Ask for price |
MC Cellufine A-200 |
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| 19-611-51 | JNC America | 5 x 1 ml | EUR 217 |
MC Cellufine GH-25 |
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| 19-711-55 | JNC America | 5 x 5 ml | EUR 430 |
MC Cellufine C-500 |
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| 19-800-51 | JNC America | 5 x 1 ml | EUR 217 |
MC Cellufine C-500 |
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| 19-800-55 | JNC America | 5 x 5 ml | EUR 345 |
MC Cellufine A-500 |
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| 19-805-51 | JNC America | 5 x 1 ml | EUR 217 |
The newest developments in imaging fibroblast activation protein (FAP)
Fibroblast activation protein (FAP), a membrane-anchored peptidase, is extremely expressed in cancer-associated fibroblasts (CAFs) in additional than 90% of epithelial tumors and contributes to development and worse prognosis of various cancers. Due to this fact, FAP is taken into account a promising goal for radionuclide-based approaches for analysis and therapy of tumors and for the analysis of non-malignant ailments related to a reworking of the extracellular matrix.
Accordingly, a wide range of quinolone-based FAP inhibitors (FAPI) coupled to chelators had been developed displaying particular binding to human and murine FAP with a speedy and nearly full internalization. On account of a excessive tumor uptake and a really low accumulation in regular tissues in addition to a speedy clearance from the circulation, a high-contrast is obtained for FAPI-PET/CT imaging even at 10 minutes after tracer administration.
Furthermore, FAPI-PET/CT gives benefits over FDG-PET/CT in a number of tumor entities for preliminary staging and detection of tumor recurrence and metastases together with peritonitis carcinomatosa.
Autoimmunity linked protein phosphatase PTPN22 as a goal for most cancers immunotherapy
Background: Most cancers immunotherapy has advanced from interferon-alpha (IFNα) and interleukin-2 within the 1980s to CTLA-Four and PD-1/PD-L1 checkpoint inhibitors (CPIs), the latter highlighting the significance of enhancing T-cell features.
Whereas the seek for novel immunomodulatory pathways continues, mixture therapies augmenting a number of pathways may enhance efficacy. The affiliation of autoimmune-related antagonistic occasions with medical efficacy following CPI therapy has been inferred and means that breaking tolerance thresholds related to autoimmunity might have an effect on host immune responses for efficient most cancers immunotherapy.
Outcomes: Right here, we present that lack of autoimmune related PTPN22, a key desensitization node for a number of signaling pathways, together with IFNα receptor (IFNAR) and T-cell receptor, can increase tumor responses. Implantation of syngeneic tumors in Ptpn22-/- mice led to growth and activation of peripheral and intratumoral T cells and, in flip, spontaneous tumor regression in addition to enhanced responses together with anti-PD-L1 therapy.
Utilizing genetically modified mice expressing a catalytically inactive PTPN22 or the autoimmunity-associated human single-nucleotide polymorphism variant, augmentation of antitumor immunity was depending on PTPN22 phosphatase exercise and partially on its adaptor features.
Additional, antitumor responses had been depending on each CD4+ and CD8+T cells and, partly, IFNAR perform. Lastly, we reveal that the autoimmune susceptibility Ptpn22(C1858T) variant is related to decrease danger of creating non-melanoma pores and skin cancers, improved general survival and elevated danger for growth of hyperthyroidism or hypothyroidism following atezolizumab (anti-PD-L1) therapy.
Conclusions: Collectively, these knowledge recommend that inhibition of PTPN22 phosphatase exercise might present an efficient therapeutic possibility for most cancers immunotherapy and that exploring genetic variants that shift immune tolerance thresholds might function a paradigm for locating new most cancers immunotherapy targets.
Recombinant Proteins Co-Expressed and Co-Purified within the Presence of Antibody Fragments
Recombinant antibodies in single-domain format (VHHs) have been lately used for stabilizing antigens throughout their purification and crystallization. VHHs are additionally recognized for his or her structural stability and a big a part of them share the attribute of remaining functionally folded additionally within the absence of the interior disulfide bond.
Due to this fact, they are often expressed as intrabodies within the cell cytoplasm in addition to within the bacterial periplasm. This proof implies that, in idea, VHHs may be co-expressed with their antigens independently on the redox constrains.
It has additionally urged the concept of utilizing co-expression and co-purification of antigen-antibody complexes for maximizing the stabilizing impact of the antibody on its antigen throughout all of the manufacturing steps for each cytoplasmic and periplasmic expression methods.
An Orthogonal Fusion Tag for Environment friendly Protein Purification
On this chapter, we current an environment friendly methodology for stringent protein purification facilitated by a twin affinity tag known as ABDz1, which is predicated on a 5 kDa albumin-binding area from Streptococcal Protein G. The small fusion tag allows an orthogonal affinity purification method based mostly on two successive and extremely particular affinity purification steps.
This method is enabled by native binding of ABDz1 to human serum albumin and engineered binding to Staphylococcal Protein A, respectively. The ABDz1-tag may be fused to both terminus of a protein of curiosity and the purification steps may be carried out utilizing commonplace laboratory gear.
MIP-3 beta Recombinant Protein |
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| 40-354-0005mg | ProSci | 0.005 mg | EUR 259.25 |
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Description: MIP-3 beta is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3 beta is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3 beta is active on murine cells. Recombinant murine MIP-3 beta is a 9.2 kDa protein containing 83 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. |
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MIP-3 beta Recombinant Protein |
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| 40-354-002mg | ProSci | 0.02 mg | EUR 364.25 |
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Description: MIP-3 beta is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3 beta is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3 beta is active on murine cells. Recombinant murine MIP-3 beta is a 9.2 kDa protein containing 83 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. |
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MIP-3 beta Recombinant Protein |
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| 40-381-0005mg | ProSci | 0.005 mg | EUR 259.25 |
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Description: MIP-3 beta is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3 beta is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3 beta is active on murine cells. Recombinant human MIP-3 beta is an 8.8 kDa protein containing 77 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. |
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MIP-3 beta Recombinant Protein |
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| 40-381-002mg | ProSci | 0.02 mg | EUR 364.25 |
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Description: MIP-3 beta is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3 beta is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3 beta is active on murine cells. Recombinant human MIP-3 beta is an 8.8 kDa protein containing 77 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. |
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MIP-3 beta, CCL19, murine (mouse) |
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| RC335-20 | Bio Basic | 5ug | EUR 101.33 |
Anti-MIP- beta antibody |
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| STJ96572 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Rabbit polyclonal to MIP-1beta. |
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Anti-MIP- beta antibody |
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| STJ94131 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Rabbit polyclonal to MIP-3beta. |
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rHu MIP-1-beta |
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| AK8264-0002 | Akron Biotech | 2µg | Ask for price |
rHu MIP-1-beta |
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| AK8264-0010 | Akron Biotech | 10µg | Ask for price |
rHu MIP-1-beta |
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| AK8264-0100 | Akron Biotech | 100µg | Ask for price |
rHu MIP-1-beta |
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| AK8264-1000 | Akron Biotech | 1mg | Ask for price |
MIP-1-beta Antibody |
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| 5249-100 | Biovision | EUR 338 | |
MIP 1 beta antibody |
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| 20R-1789 | Fitzgerald | 100 ug | EUR 673 |
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Description: Rabbit polyclonal MIP 1 beta antibody |
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rM IL-2 |
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| AK8323-0005 | Akron Biotech | 5µg | Ask for price |
rM IL-2 |
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| AK8323-0020 | Akron Biotech | 20µg | Ask for price |
rM IL-2 |
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| AK8323-0100 | Akron Biotech | 100µg | Ask for price |
rM IL-2 |
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| AK8323-1000 | Akron Biotech | 1mg | Ask for price |
Recombinant Human MIP-3 Beta (CCL19) Protein |
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| PROTQ99731-1 | BosterBio | 20ug | EUR 317 |
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Description: MIP-3β is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3β is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3β is active on murine cells. Recombinant human MIP-3β is an 8.8 kDa protein containing 77 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. |
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Recombinant Murine MIP-3 Beta (CCL19) Protein |
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| PROTO70460-2 | BosterBio | 20ug | EUR 317 |
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Description: MIP-3β is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3β is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3β is active on murine cells. Recombinant murine MIP-3β is a 9.2 kDa protein containing 83 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. |
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Human CCL19/MIP-3 beta ELISA Kit |
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| LF-EK50840 | Abfrontier | 1×96T | EUR 648 |
Anti-14-3-3 alpha + beta Rabbit Monoclonal Antibody |
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| M02431-3 | BosterBio | 100ug/vial | EUR 397 |
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Description: Rabbit Monoclonal 14-3-3 alpha + beta Antibody. Validated in Flow Cytometry, IP, IF, IHC, ICC, WB and tested in Human, Mouse, Rat. |
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MIP-3 |
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| EF017888 | Lifescience Market | 96 Tests | EUR 689 |
MIP-3 |
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| EF013760 | Lifescience Market | 96 Tests | EUR 689 |
MIP-3 |
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| EF013761 | Lifescience Market | 96 Tests | EUR 689 |
MIP-3 |
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| EF016652 | Lifescience Market | 96 Tests | EUR 689 |
MIP-3 |
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| EF016984 | Lifescience Market | 96 Tests | EUR 689 |
MIP-3 |
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| EF010865 | Lifescience Market | 96 Tests | EUR 689 |
MIP-3 |
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| EF012726 | Lifescience Market | 96 Tests | EUR 689 |
MIP-3 |
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| PAab09791 | Lifescience Market | 100 ug | EUR 386 |
1 mm Gaskets 3/pk, RM |
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| 2398237 | Atto | 5unit | EUR 257 |
MIP-1 beta, CCL4, human |
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| RC314-15 | Bio Basic | 2ug | EUR 101.33 |
MIP-1 beta, CCL4, rat |
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| RC355-15 | Bio Basic | 5ug | EUR 104.38 |
MIP-1-beta/CCL4, Human |
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| HY-P7257 | MedChemExpress | 10ug | EUR 268 |
MIP-1 beta Recombinant Protein |
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| 40-358-0002mg | ProSci | 0.002 mg | EUR 259.25 |
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Description: Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1 alpha and MIP-1 beta are active on human and murine hematopoietic cells. Recombinant murine MIP-1 beta is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. |
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MIP-1 beta Recombinant Protein |
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| 40-358-001mg | ProSci | 0.01 mg | EUR 364.25 |
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Description: Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1 alpha and MIP-1 beta are active on human and murine hematopoietic cells. Recombinant murine MIP-1 beta is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. |
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MIP-1 beta Recombinant Protein |
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| 40-365-0002mg | ProSci | 0.002 mg | EUR 259.25 |
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Description: Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1 alpha and MIP-1 beta are active on human and murine hematopoietic cells. Recombinant human MIP-1 betais a 7.6 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. |
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MIP-1 beta Recombinant Protein |
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| 40-365-001mg | ProSci | 0.01 mg | EUR 364.25 |
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Description: Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1 alpha and MIP-1 beta are active on human and murine hematopoietic cells. Recombinant human MIP-1 betais a 7.6 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. |
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MIP-1 beta Recombinant Protein |
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| 40-407-0005mg | ProSci | 0.005 mg | EUR 259.25 |
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Description: Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1 alpha and MIP-1 beta are active on human and murine hematopoietic cells. Recombinant rat MIP-1 beta is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. |
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MIP-1 beta Recombinant Protein |
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| 40-407-002mg | ProSci | 0.02 mg | EUR 364.25 |
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Description: Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1 alpha and MIP-1 beta are active on human and murine hematopoietic cells. Recombinant rat MIP-1 beta is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. |
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Clips 4/pk RM |
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| 2398239 | Atto | 6unit | EUR 250 |
1mm Pressure Platen - RM |
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| 2398242 | Atto | 3unit | EUR 281 |
Anti-CCL19/Mip 3 Beta Rabbit Monoclonal Antibody |
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| M01605 | BosterBio | 100ug/vial | EUR 397 |
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Description: Rabbit Monoclonal CCL19/Mip 3 Beta Antibody. Validated in WB and tested in Human. |
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Rabbit Anti Human Mip-3 Beta Polyclonal Antibody |
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| CPBT-65218RH | Creative Diagnostics | 0.1 mg | EUR 881 |
ELISA kit for Human CCL19/MIP-3 Beta |
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| EK5194 | SAB | 96 tests | EUR 553 |
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Description: Enzyme-linked immunosorbent assay kit for quantification of Human CCL19/MIP-3 Beta in samples from serum, plasma, tissue homogenates and other biological fluids. |
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ELISA kit for Mouse CCL19/MIP-3 beta |
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| EK5195 | SAB | 96 tests | EUR 553 |
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Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse CCL19/MIP-3 beta in samples from serum, plasma, tissue homogenates and other biological fluids. |
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TGF-b-3 Transforming Growth Factor-Beta 3 Human Recombinant Protein, Plant |
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| PROTP10600-3 | BosterBio | Regular: 5ug | EUR 317 |
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Description: TGFB3 Human Recombinant produced in plant is a disulfide-linked homodimeric, glycosylated, polypeptide chain containing 118 amino acids and having a molecular mass of 27.2kDa. ;The TGFB3 is fused to 6xHis tag at N-terminus and purified by standard chromatographic techniques. |
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anti- MIP-3 |
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| LSMab09791 | Lifescience Market | 100 ug | EUR 386 |
Anti-IL1 beta Antibody |
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| A00101-3 | BosterBio | 100ug | EUR 455 |
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Description: Rabbit Polyclonal IL1 beta Antibody. Validated in IP, IF, IHC, WB and tested in Mouse, Rat. |
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MIP-1 beta, CCL4, murine (mouse) |
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| RC335-15 | Bio Basic | 2ug | EUR 104.38 |
Pig MIP-1 Beta (CCL4) Protein |
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| abx670310-5ug | Abbexa | 5 ug | EUR 411 |
GRO beta / MIP-2 (CXCL2) Protein |
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| 20-abx261572 | Abbexa |
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GRO beta / MIP-2 (CXCL2) Protein |
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| 20-abx261590 | Abbexa |
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GRO beta / MIP-2 (CXCL2) Protein |
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| 20-abx261604 | Abbexa |
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MIP-1 beta (human) ELISA Kit |
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| K4785-100 | Biovision | 100 assays | EUR 809 |
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Description: Sensitive, Colorimetric Assay |
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GRO-beta/MIP-2, rat recombinant |
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| 4108-1000 | Biovision | EUR 3965 | |
GRO-beta/MIP-2, rat recombinant |
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| 4108-20 | Biovision | EUR 262 | |
MIP-2/Gro-beta, murine recombinant |
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| 4251-1000 | Biovision | EUR 5204 | |
MIP-2/Gro-beta, murine recombinant |
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| 4251-20 | Biovision | EUR 297 | |
Rabbit Anti Human Mip-3 Beta Polyclonal Antibody,Biotin |
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| CPBT-65217RH | Creative Diagnostics | 50 µg | EUR 881 |
1 mm Preparative Comb, RM |
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| 2328934 | Atto | 3unit | EUR 253 |
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Description: 1 sampl e wel l and 1 r efer ence wel l |
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0.75mm Plate Set,RM-075 |
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| 2393014 | Atto | 2unit | EUR 263 |
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Description: 1 pai r of gl ass pl at es + 1 gask et , for 0.75 mm gel |
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5 mm Dummy Plate, RM |
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| 2393074 | Atto | 10unit | EUR 241 |
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Description: Pl ast i c pl at e for r unni ng 1 Pagel pr ecast gel onl y |
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2mm Plate Set,RM-22 |
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| 2393740 | Atto | 3unit | EUR 281 |
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Description: 1 pai r of gl ass pl at es + 1 gask et , for 2 mm gel |
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7 mm Dummy Plate, RM |
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| 2398247 | Atto | 10unit | EUR 241 |
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Description: Pl ast i c pl at e for r unni ng 1 hand-cast gel onl y |
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1 mm Blank Comb, RM |
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| 2399041 | Atto | 4unit | EUR 272 |
Anti- Beta-tubulin Monoclonal Antibody |
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| M05613-3 | BosterBio | 100ul | EUR 397 |
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Description: Mouse Monoclonal Beta-tubulin Antibody. Validated in IHC, WB and tested in Human, Monkey, Mouse, Rat. |
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Recombinant Human IFN-Beta Protein |
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| PROTP01574-3 | BosterBio | 20ug | EUR 317 |
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Description: Proteins of this family play an important role in inducing non-specific resistance against a broad range of viral infections. They also affect cell proliferation and modulate immune responses. Produced by peripheral blood leukocytes and lymphoblastoid cells, IFNα is an acid stable molecule that signals through IFNα/βR, which is also used by IFNβ. Both IFNs have similar anti-viral activity and regulate expression of MHC class I antigens. IFNα contains four highly conserved cysteine residues which form two disulfide bonds, one of which is necessary for biological activity. Recombinant human IFNβ is an 20.0 kDa protein containing 166 amino acid residues. Due to glycosylation, IFNβ has an approximate MW of 22.3 kDa based on SDS-PAGE gel and Mass Spectrometry. *Human IFN-β(Catalog Number 300-02BC) has replaced Human IFN-β(Catalog Number 300-02B) |
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Swine IFN beta Recombinant Protein |
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| R02041-3 | BosterBio | 5ug/vial | EUR 259 |
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Description: IFN beta is a mammalian Type I interferon, functioning as a regulator of cellular activity by interacting with cell-surface receptors and activating various signaling pathways. IFN beta produces antiviral, antibacterial, and anticancer properties. Swine IFN beta Recombinant Protein is purified IFN beta produced in yeast. |
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Anti-GLB1/Beta-galactosidase Antibody |
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| A01829-3 | BosterBio | 100ug/vial | EUR 334 |
Anti-Beta Tubulin Antibody (monoclonal, 5E4) |
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| M01857-3 | BosterBio | 100ug/vial | EUR 294 |
Recombinant Human IL-1 Beta Protein |
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| PROTP01584-3 | BosterBio | 10ug | EUR 317 |
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Description: IL-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant human IL-1β is a 17.3 kDa protein containing 153 amino acid residues. |
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Equine IL-1 beta Recombinant Protein |
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| R00101-3 | BosterBio | 5ug/vial | EUR 259 |
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Description: IL-1 beta (IL-1β) is a member of the interleukin 1 family of cytokines. The IL-1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. Equine IL-1 beta Recombinant Protein is purified interleukin-1 beta cytokine produced in yeast. |
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Anti-beta 2 Microglobulin/B2m Antibody |
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| A00456-3 | BosterBio | 100ug/vial | EUR 294 |
MIP-3? Polyclonal Antibody |
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| ES8712-100ul | ELK Biotech | 100ul | EUR 279 |
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Description: A Rabbit Polyclonal antibody against MIP-3? from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA |
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MIP-3? Polyclonal Antibody |
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| ES8712-50ul | ELK Biotech | 50ul | EUR 207 |
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Description: A Rabbit Polyclonal antibody against MIP-3? from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA |
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MIP-3? Polyclonal Antibody |
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| ES7130-100ul | ELK Biotech | 100ul | EUR 279 |
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Description: A Rabbit Polyclonal antibody against MIP-3? from Human. This antibody is tested and validated for IHC, WB, ELISA |
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MIP-3? Polyclonal Antibody |
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| ES7130-50ul | ELK Biotech | 50ul | EUR 207 |
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Description: A Rabbit Polyclonal antibody against MIP-3? from Human. This antibody is tested and validated for IHC, WB, ELISA |
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MIP-3, CCL23, human |
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| RC315-34 | Bio Basic | 5ug | EUR 104.38 |
rHu MIP-3-alpha |
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| AK8271-0005 | Akron Biotech | 5µg | Ask for price |
rHu MIP-3-alpha |
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| AK8271-0020 | Akron Biotech | 20µg | Ask for price |
rHu MIP-3-alpha |
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| AK8271-0100 | Akron Biotech | 100µg | Ask for price |
rHu MIP-3-alpha |
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| AK8271-1000 | Akron Biotech | 1mg | Ask for price |
MIP-3 Recombinant Protein |
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| 40-379-0005mg | ProSci | 0.005 mg | EUR 259.25 |
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Description: MIP-3 is a CC chemokine that signals through the CCR1 receptor. MIP-3 chemoattracts monocytes, resting T-lymphocytes and neutrophils, but does not chemoattract activated lymphocytes. Additionally, MIP-3 has been shown to inhibit colony formation of bone marrow myeloid immature progenitors. Recombinant human MIP-3 is an 11.3 kDa protein containing 99 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. |
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MIP-3 Recombinant Protein |
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| 40-379-002mg | ProSci | 0.02 mg | EUR 364.25 |
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Description: MIP-3 is a CC chemokine that signals through the CCR1 receptor. MIP-3 chemoattracts monocytes, resting T-lymphocytes and neutrophils, but does not chemoattract activated lymphocytes. Additionally, MIP-3 has been shown to inhibit colony formation of bone marrow myeloid immature progenitors. Recombinant human MIP-3 is an 11.3 kDa protein containing 99 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. |
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Recombinant Mouse MIP-3 beta/ CCL19 Protein, Untagged, E.coli-100ug |
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| QP10273-ec-100ug | EnQuireBio | 100ug | EUR 988 |
Recombinant Mouse MIP-3 beta/ CCL19 Protein, Untagged, E.coli-20ug |
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| QP10273-ec-20ug | EnQuireBio | 20ug | EUR 290 |
Recombinant Mouse MIP-3 beta/ CCL19 Protein, Untagged, E.coli-250ug |
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| QP10273-ec-250ug | EnQuireBio | 250ug | EUR 1731 |
Recombinant Mouse MIP-3 beta/ CCL19 Protein, Untagged, E.coli-5ug |
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| QP10273-ec-5ug | EnQuireBio | 5ug | EUR 154 |
Recombinant Mouse MIP-3 beta/ CCL19 Protein, Untagged, E.coli-1mg |
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| QP5219-1mg | EnQuireBio | 1mg | EUR 2856 |
Recombinant Mouse MIP-3 beta/ CCL19 Protein, Untagged, E.coli-500ug |
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| QP5219-500ug | EnQuireBio | 500ug | EUR 1778 |
Recombinant Human MIP-3 beta/ CCL19 Protein, Untagged, E.coli-100ug |
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| QP5258-100ug | EnQuireBio | 100ug | EUR 490 |
Recombinant Human MIP-3 beta/ CCL19 Protein, Untagged, E.coli-1mg |
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| QP5258-1mg | EnQuireBio | 1mg | EUR 2856 |