thebarkerlab

Toll-interacting protein impacts on inflammation, autophagy

Posted on by Robert

Toll-interacting protein impacts on irritation, autophagy, and vacuole trafficking in human illness

Toll-interacting protein (TOLLIP) is a ubiquitous intracellular adaptor protein concerned in a number of intracellular signaling pathways. It performs a key position in mediating inflammatory intracellular responses, selling autophagy, and enabling vacuole transport throughout the cell. TOLLIP is being more and more acknowledged for its position in illness pathophysiology by way of involvement in these three main pathways. Current analysis additionally signifies that TOLLIP is concerned in nuclear-cytoplasmic switch, though this space requires additional exploration. TOLLIP is concerned within the pathophysiologic pathways related to neurodegenerative ailments, pulmonary ailments, heart problems, inflammatory bowel illness, and malignancy.

We postulate that TOLLIP performs an integral position within the illness pathophysiology of different situations concerned in vacuole trafficking and autophagy. We propose that future analysis on this discipline ought to examine the position of TOLLIP antibodies within the pathogenesis of those a number of situations.

This analysis has the potential to tell illness mechanisms and determine novel alternatives for therapeutic advances in a number of illness processes

Molecular docking-assisted screening reveals tannic acid as a pure protein disulphide isomerase inhibitor with antiplatelet and antithrombotic actions

Protein disulphide isomerase (PDI) promotes platelet activation and constitutes a novel antithrombotic goal. On this examine, we reported {that a} PDI-binding plant polyphenol, tannic acid (TA), inhibits PDI exercise, platelet activation and thrombus formation.

Molecular docking utilizing plant polyphenols from dietary sources with cardiovascular advantages revealed TA as probably the most potent binding molecule with PDI energetic centre. Floor plasmon resonance demonstrated that TA certain PDI with excessive affinity. Utilizing Di-eosin-glutathione disulphide fluorescence assay and PDI assay package, we confirmed that TA inhibited PDI exercise.

In remoted platelets, TA inhibited platelet aggregation stimulated by both GPVI or ITAM pathway agonists. Stream cytometry confirmed that TA inhibited thrombin- or CRP-stimulated platelet activation, as mirrored by diminished granule secretion and integrin activation. TA additionally diminished platelet spreading on immobilized fibrinogen and platelet adhesion below move situations.

In a laser-induced vascular harm mouse mannequin, intraperitoneal injection of TA considerably decreased the dimensions of cremaster arteriole thrombi. No prolongation of mouse jugular vein and tail-bleeding time was noticed after TA administration. Due to this fact, we recognized TA from pure polyphenols as a novel inhibitor of PDI perform. TA inhibits platelet activation and thrombus formation, suggesting it as a possible antithrombotic agent.

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19846 500 ml
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20-854 500 ml
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676-943-324 10 ml
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676-944-324 10 ml
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670000327 100 ml
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673980327 100 ml
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681-984-324 10 ml
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19-611-51 5 x 1 ml
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19-800-51 5 x 1 ml
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19-800-55 5 x 5 ml
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19-805-51 5 x 1 ml
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19-805-55 5 x 5 ml
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21-000-51 5 x 1 ml
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21-100-55 5 x 5 ml
EUR 537.00

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21-200-51 5 x 1 ml
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21-200-55 5 x 5 ml
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21-300-55 5 x 5 ml
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21-500-15 1 x 5 ml
EUR 451.00

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21-500-51 5 x 1 ml
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21-600-15 1 x 5 ml
EUR 302.00

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21-600-51 5 x 1 ml
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21-700 10 ml
EUR 260.00

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21-700-15 1 x 5 ml
EUR 302.00

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21-700-51 5 x 1 ml
EUR 302.00

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EUR 484.00

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21-702 500 ml
EUR 2402.00

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21-800 10 ml
EUR 260.00

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21-900-11 1 x 1 ml
EUR 372.00

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21-900-15 1 x 5 ml
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21-900-51 5 x 1 ml
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20800 100 ml
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20801 500 ml
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20-401 500 ml
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The newest developments in imaging fibroblast activation protein (FAP)

Fibroblast activation protein (FAP), a membrane-anchored peptidase, is extremely expressed in cancer-associated fibroblasts (CAFs) in additional than 90% of epithelial tumors and contributes to development and worse prognosis of various cancers. Due to this fact, FAP is taken into account a promising goal for radionuclide-based approaches for analysis and therapy of tumors and for the analysis of non-malignant ailments related to a reworking of the extracellular matrix.
Accordingly, a wide range of quinolone-based FAP inhibitors (FAPI) coupled to chelators had been developed displaying particular binding to human and murine FAP with a speedy and nearly full internalization. On account of a excessive tumor uptake and a really low accumulation in regular tissues in addition to a speedy clearance from the circulation, a high-contrast is obtained for FAPI-PET/CT imaging even at 10 minutes after tracer administration.
Furthermore, FAPI-PET/CT gives benefits over FDG-PET/CT in a number of tumor entities for preliminary staging and detection of tumor recurrence and metastases together with peritonitis carcinomatosa.

Autoimmunity linked protein phosphatase PTPN22 as a goal for most cancers immunotherapy

Background: Most cancers immunotherapy has advanced from interferon-alpha (IFNα) and interleukin-2 within the 1980s to CTLA-Four and PD-1/PD-L1 checkpoint inhibitors (CPIs), the latter highlighting the significance of enhancing T-cell features.
Whereas the seek for novel immunomodulatory pathways continues, mixture therapies augmenting a number of pathways may enhance efficacy. The affiliation of autoimmune-related antagonistic occasions with medical efficacy following CPI therapy has been inferred and means that breaking tolerance thresholds related to autoimmunity might have an effect on host immune responses for efficient most cancers immunotherapy.
Outcomes: Right here, we present that lack of autoimmune related PTPN22, a key desensitization node for a number of signaling pathways, together with IFNα receptor (IFNAR) and T-cell receptor, can increase tumor responses. Implantation of syngeneic tumors in Ptpn22-/- mice led to growth and activation of peripheral and intratumoral T cells and, in flip, spontaneous tumor regression in addition to enhanced responses together with anti-PD-L1 therapy.
Utilizing genetically modified mice expressing a catalytically inactive PTPN22 or the autoimmunity-associated human single-nucleotide polymorphism variant, augmentation of antitumor immunity was depending on PTPN22 phosphatase exercise and partially on its adaptor features.
Additional, antitumor responses had been depending on each CD4+ and CD8+T cells and, partly, IFNAR perform. Lastly, we reveal that the autoimmune susceptibility Ptpn22(C1858T) variant is related to decrease danger of creating non-melanoma pores and skin cancers, improved general survival and elevated danger for growth of hyperthyroidism or hypothyroidism following atezolizumab (anti-PD-L1) therapy.
Conclusions: Collectively, these knowledge recommend that inhibition of PTPN22 phosphatase exercise might present an efficient therapeutic possibility for most cancers immunotherapy and that exploring genetic variants that shift immune tolerance thresholds might function a paradigm for locating new most cancers immunotherapy targets.

Recombinant Proteins Co-Expressed and Co-Purified within the Presence of Antibody Fragments

Recombinant antibodies in single-domain format (VHHs) have been lately used for stabilizing antigens throughout their purification and crystallization. VHHs are additionally recognized for his or her structural stability and a big a part of them share the attribute of remaining functionally folded additionally within the absence of the interior disulfide bond.
Due to this fact, they are often expressed as intrabodies within the cell cytoplasm in addition to within the bacterial periplasm. This proof implies that, in idea, VHHs may be co-expressed with their antigens independently on the redox constrains.
It has additionally urged the concept of utilizing co-expression and co-purification of antigen-antibody complexes for maximizing the stabilizing impact of the antibody on its antigen throughout all of the manufacturing steps for each cytoplasmic and periplasmic expression methods.

An Orthogonal Fusion Tag for Environment friendly Protein Purification

On this chapter, we current an environment friendly methodology for stringent protein purification facilitated by a twin affinity tag known as ABDz1, which is predicated on a 5 kDa albumin-binding area from Streptococcal Protein G. The small fusion tag allows an orthogonal affinity purification method based mostly on two successive and extremely particular affinity purification steps.
This method is enabled by native binding of ABDz1 to human serum albumin and engineered binding to Staphylococcal Protein A, respectively. The ABDz1-tag may be fused to both terminus of a protein of curiosity and the purification steps may be carried out utilizing commonplace laboratory gear.

MIP-3-beta Antibody
abx235194-100ug 100 ug
EUR 481.00
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anti- MIP-3-beta antibody
FNab05194 100µg
EUR 505.25
  • Immunogen: chemokine(C-C motif) ligand 19
  • Uniprot ID: Q99731
  • Research Area: Immunology, Signal Transduction
Description: Antibody raised against MIP-3-beta

MIP-3-beta/CCL19, Mouse
HY-P7264 50ug
EUR 533.00

Anti-MIP-3-beta antibody
PAab05194 100 ug
EUR 355.00

MIP-3 beta, CCL19, murine (mouse)
RC335-20 5ug
EUR 101.33
  • Product category: Proteins/Recombinant Proteins/Cytokines

rHu MIP-1-beta
AK8264-0002 2µg Ask for price

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AK8264-0010 10µg Ask for price

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AK8264-0100 100µg Ask for price

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AK8264-1000 1mg Ask for price

MIP-1-beta Antibody
5249-100
EUR 338.00

MIP 1 beta antibody
20R-1789 100 ug
EUR 673.00
Description: Rabbit polyclonal MIP 1 beta antibody

Anti-MIP- beta antibody
STJ94131 200 µl
EUR 197.00
Description: Rabbit polyclonal to MIP-3beta.

Anti-MIP- beta antibody
STJ96572 200 µl
EUR 197.00
Description: Rabbit polyclonal to MIP-1beta.

rM IL-2
AK8323-0005 5µg Ask for price

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AK8323-0020 20µg Ask for price

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AK8323-0100 100µg Ask for price

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AK8323-1000 1mg Ask for price

Recombinant Murine MIP-3 Beta (CCL19) Protein
PROTO70460-2 20ug
EUR 317.00
Description: MIP-3β is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3β is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3β is active on murine cells. Recombinant murine MIP-3β is a 9.2 kDa protein containing 83 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Human CCL19/MIP-3 beta ELISA Kit
LF-EK50840 1×96T
EUR 648.00

Recombinant Human MIP-3 Beta (CCL19) Protein
PROTQ99731-1 20ug
EUR 317.00
Description: MIP-3β is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3β is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3β is active on murine cells. Recombinant human MIP-3β is an 8.8 kDa protein containing 77 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

MIP-3
EF016652 96 Tests
EUR 689.00

MIP-3
EF016984 96 Tests
EUR 689.00

MIP-3
EF017888 96 Tests
EUR 689.00

MIP-3
EF012726 96 Tests
EUR 689.00

MIP-3
EF013760 96 Tests
EUR 689.00

MIP-3
EF013761 96 Tests
EUR 689.00

MIP-3
EF010865 96 Tests
EUR 689.00

MIP-3
PAab09791 100 ug
EUR 386.00

Anti-14-3-3 alpha + beta Rabbit Monoclonal Antibody
M02431-3 100ug/vial
EUR 397.00
Description: Rabbit Monoclonal 14-3-3 alpha + beta Antibody. Validated in Flow Cytometry, IP, IF, IHC, ICC, WB and tested in Human, Mouse, Rat.

1 mm Gaskets 3/pk, RM
2398237 5unit
EUR 257.00

MIP-1-beta/CCL4, Human
HY-P7257 10ug
EUR 268.00

MIP-1 beta, CCL4, human
RC314-15 2ug
EUR 101.33
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MIP-1 beta, CCL4, rat
RC355-15 5ug
EUR 104.38
  • Product category: Proteins/Recombinant Proteins/Cytokines

ELISA kit for Human CCL19/MIP-3 Beta
EK5194 96 tests
EUR 553.00
Description: Enzyme-linked immunosorbent assay kit for quantification of Human CCL19/MIP-3 Beta in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Mouse CCL19/MIP-3 beta
EK5195 96 tests
EUR 553.00
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse CCL19/MIP-3 beta in samples from serum, plasma, tissue homogenates and other biological fluids.

Human CCL19/MIP-3 beta PicoKine ELISA Kit
EK0456 96 wells
EUR 425.00
Description: For quantitative detection of human CCL19 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Mouse CCL19/MIP-3 beta PicoKine ELISA Kit
EK0457 96 wells
EUR 425.00
Description: For quantitative detection of mouse CCL19 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Rabbit Anti Human Mip-3 Beta Polyclonal Antibody
CPBT-65218RH 0.1 mg
EUR 881.00

Anti-CCL19/Mip 3 Beta Rabbit Monoclonal Antibody
M01605 100ug/vial
EUR 397.00
Description: Rabbit Monoclonal CCL19/Mip 3 Beta Antibody. Validated in WB and tested in Human.

Clips 4/pk RM
2398239 6unit
EUR 250.00

1mm Pressure Platen - RM
2398242 3unit
EUR 281.00

TGF-b-3 Transforming Growth Factor-Beta 3 Human Recombinant Protein, Plant
PROTP10600-3 Regular: 5ug
EUR 317.00
Description: TGFB3 Human Recombinant produced in plant is a disulfide-linked homodimeric, glycosylated, polypeptide chain containing 118 amino acids and having a molecular mass of 27.2kDa. ;The TGFB3 is fused to 6xHis tag at N-terminus and purified by standard chromatographic techniques.

anti- MIP-3
LSMab09791 100 ug
EUR 386.00

Pig MIP-1 Beta (CCL4) Protein
abx670310-5ug 5 ug
EUR 411.00
  • Shipped within 1 week.

GRO beta / MIP-2 (CXCL2) Protein
20-abx261572
  • EUR 328.00
  • EUR 3418.00
  • EUR 230.00
  • 0
  • 1
  • 2
  • Shipped within 5-10 working days.

GRO beta / MIP-2 (CXCL2) Protein
20-abx261590
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 0
  • 1
  • 2
  • Shipped within 5-10 working days.

GRO beta / MIP-2 (CXCL2) Protein
20-abx261604
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 0
  • 1
  • 2
  • Shipped within 5-10 working days.

MIP-2/Gro-beta, murine recombinant
4251-1000
EUR 5204.00

MIP-2/Gro-beta, murine recombinant
4251-20
EUR 297.00

GRO-beta/MIP-2, rat recombinant
4108-1000
EUR 3965.00

GRO-beta/MIP-2, rat recombinant
4108-20
EUR 262.00

MIP-1 beta (human) ELISA Kit
K4785-100 100 assays
EUR 809.00
  • Kit components:
  • MIP-1 β antibody-coated Microplate (Item A), 96 wells
  • Wash Buffer (20x) (Item B)
  • rh MIP-1 β Standards (Item C)
  • Assay Diluent A (Item D)
  • Assay Diluent B (5x) (Item E)
  • MIP-1 β Detection Antibody (Item F)
  • HRP-St
  • Show more
Description: Sensitive, Colorimetric Assay

MIP-1 beta, CCL4, murine (mouse)
RC335-15 2ug
EUR 104.38
  • Product category: Proteins/Recombinant Proteins/Cytokines

Rabbit Anti Human Mip-3 Beta Polyclonal Antibody,Biotin
CPBT-65217RH 50 µg
EUR 881.00

Anti-IL1 beta Antibody
A00101-3 100ug
EUR 455.00
Description: Rabbit Polyclonal IL1 beta Antibody. Validated in IP, IF, IHC, WB and tested in Mouse, Rat.

1 mm Preparative Comb, RM
2328934 3unit
EUR 253.00
Description: 1 sampl e wel l and 1 r efer ence wel l

0.75mm Plate Set,RM-075
2393014 2unit
EUR 263.00
Description: 1 pai r of gl ass pl at es + 1 gask et , for 0.75 mm gel

5 mm Dummy Plate, RM
2393074 10unit
EUR 241.00
Description: Pl ast i c pl at e for r unni ng 1 Pagel pr ecast gel onl y

2mm Plate Set,RM-22
2393740 3unit
EUR 281.00
Description: 1 pai r of gl ass pl at es + 1 gask et , for 2 mm gel

7 mm Dummy Plate, RM
2398247 10unit
EUR 241.00
Description: Pl ast i c pl at e for r unni ng 1 hand-cast gel onl y

1 mm Blank Comb, RM
2399041 4unit
EUR 272.00

Anti-GLB1/Beta-galactosidase Antibody
A01829-3 100ug/vial
EUR 334.00

Recombinant Human IFN-Beta Protein
PROTP01574-3 20ug
EUR 317.00
Description: Proteins of this family play an important role in inducing non-specific resistance against a broad range of viral infections. They also affect cell proliferation and modulate immune responses. Produced by peripheral blood leukocytes and lymphoblastoid cells, IFNα is an acid stable molecule that signals through IFNα/βR, which is also used by IFNβ. Both IFNs have similar anti-viral activity and regulate expression of MHC class I antigens. IFNα contains four highly conserved cysteine residues which form two disulfide bonds, one of which is necessary for biological activity. Recombinant human IFNβ is an 20.0 kDa protein containing 166 amino acid residues. Due to glycosylation, IFNβ has an approximate MW of 22.3 kDa based on SDS-PAGE gel and Mass Spectrometry.

*Human IFN-β(Catalog Number 300-02BC) has replaced Human IFN-β(Catalog Number 300-02B)

Anti- Beta-tubulin Monoclonal Antibody
M05613-3 100ul
EUR 397.00
Description: Mouse Monoclonal Beta-tubulin Antibody. Validated in IHC, WB and tested in Human, Monkey, Mouse, Rat.

Swine IFN beta Recombinant Protein
R02041-3 5ug/vial
EUR 259.00
Description: IFN beta is a mammalian Type I interferon, functioning as a regulator of cellular activity by interacting with cell-surface receptors and activating various signaling pathways. IFN beta produces antiviral, antibacterial, and anticancer properties. Swine IFN beta Recombinant Protein is purified IFN beta produced in yeast.

GRO beta / MIP-2 (CXCL2) His Protein
20-abx260689
  • EUR 328.00
  • EUR 3418.00
  • EUR 230.00
  • 0
  • 1
  • 2
  • Shipped within 5-10 working days.

Recombinant Human GRO-beta/MIP-2 (CXCL2)
7-01864 2µg Ask for price

Recombinant Human GRO-beta/MIP-2 (CXCL2)
7-01865 10µg Ask for price

Recombinant Human GRO-beta/MIP-2 (CXCL2)
7-01866 1mg Ask for price

Recombinant Mouse GRO-beta/MIP-2 (CXCL2)
7-01870 5µg Ask for price

Recombinant Mouse GRO-beta/MIP-2 (CXCL2)
7-01871 20µg Ask for price

Recombinant Mouse GRO-beta/MIP-2 (CXCL2)
7-01872 1mg Ask for price

Recombinant Rat GRO-beta/MIP-2 (CXCL2)
7-01873 5µg Ask for price

Recombinant Rat GRO-beta/MIP-2 (CXCL2)
7-01874 20µg Ask for price

Recombinant Rat GRO-beta/MIP-2 (CXCL2)
7-01875 1mg Ask for price

Recombinant Murine MIP-1 Beta (CCL4) Protein
PROTP14097-1 10ug
EUR 317.00
Description: Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1α and MIP-1β exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant murine MIP-1β is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Human CCL4/MIP-1 beta ELISA Kit
LF-EK50838 1×96T
EUR 648.00

Rat CCL4/MIP-1 beta ELISA Kit
LF-EK50964 1×96T
EUR 648.00

Mouse MIP-1-beta/CCL4 ELISA Kit
RK00072 96 Tests
EUR 521.00

Human MIP-1-beta/CCL4 ELISA Kit
RK00138 96 Tests
EUR 521.00

Recombinant Rat MIP-1 Beta (CCL4) Protein
PROTP50230-1 20ug
EUR 317.00
Description: Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1α and MIP-1β exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant rat MIP-1β is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Recombinant Human MIP-1 Beta (CCL4) Protein
PROTQ8NHW4-2 10ug
EUR 317.00
Description: Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1α and MIP-1β exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant human MIP-1βis a 7.6 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

rHu MIP-3-alpha
AK8271-0005 5µg Ask for price

rHu MIP-3-alpha
AK8271-0020 20µg Ask for price

rHu MIP-3-alpha
AK8271-0100 100µg Ask for price

rHu MIP-3-alpha
AK8271-1000 1mg Ask for price

MIP-3? Polyclonal Antibody
ES7130-100ul 100ul
EUR 279.00
Description: A Rabbit Polyclonal antibody against MIP-3? from Human. This antibody is tested and validated for IHC, WB, ELISA

MIP-3? Polyclonal Antibody
ES7130-50ul 50ul
EUR 207.00
Description: A Rabbit Polyclonal antibody against MIP-3? from Human. This antibody is tested and validated for IHC, WB, ELISA

MIP-3? Polyclonal Antibody
ES8712-100ul 100ul
EUR 279.00
Description: A Rabbit Polyclonal antibody against MIP-3? from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA

MIP-3? Polyclonal Antibody
ES8712-50ul 50ul
EUR 207.00
Description: A Rabbit Polyclonal antibody against MIP-3? from Human/Mouse. This antibody is tested and validated for IHC, WB, ELISA

MIP-3, CCL23, human
RC315-34 5ug
EUR 104.38
  • Product category: Proteins/Recombinant Proteins/Cytokines

Recombinant Human MIP-3 beta/ CCL19 Protein, GST, E.coli-100ug
QP8024-ec-100ug 100ug
EUR 408.00

Recombinant Human MIP-3 beta/ CCL19 Protein, GST, E.coli-10ug
QP8024-ec-10ug 10ug
EUR 200.00

Recombinant Human MIP-3 beta/ CCL19 Protein, GST, E.coli-1mg
QP8024-ec-1mg 1mg
EUR 1632.00

Recombinant Human MIP-3 beta/ CCL19 Protein, GST, E.coli-200ug
QP8024-ec-200ug 200ug
EUR 634.00

Recombinant Human MIP-3 beta/ CCL19 Protein, GST, E.coli-500ug
QP8024-ec-500ug 500ug
EUR 1060.00

Recombinant Human MIP-3 beta/ CCL19 Protein, GST, E.coli-50ug
QP8024-ec-50ug 50ug
EUR 263.00

Recombinant Mouse MIP-3 beta/ CCL19 Protein, Untagged, E.coli-100ug
QP10273-ec-100ug 100ug
EUR 988.00

Recombinant Mouse MIP-3 beta/ CCL19 Protein, Untagged, E.coli-20ug
QP10273-ec-20ug 20ug
EUR 290.00

Recombinant Mouse MIP-3 beta/ CCL19 Protein, Untagged, E.coli-250ug
QP10273-ec-250ug 250ug
EUR 1731.00

Recombinant Mouse MIP-3 beta/ CCL19 Protein, Untagged, E.coli-5ug
QP10273-ec-5ug 5ug
EUR 154.00

Recombinant Mouse MIP-3 beta/ CCL19 Protein, Untagged, E.coli-1mg
QP5219-1mg 1mg
EUR 2856.00

Recombinant Mouse MIP-3 beta/ CCL19 Protein, Untagged, E.coli-500ug
QP5219-500ug 500ug
EUR 1778.00

Recombinant Human MIP-3 beta/ CCL19 Protein, Untagged, E.coli-100ug
QP5258-100ug 100ug
EUR 490.00

Recombinant Human MIP-3 beta/ CCL19 Protein, Untagged, E.coli-1mg
QP5258-1mg 1mg
EUR 2856.00

Recombinant Human MIP-3 beta/ CCL19 Protein, Untagged, E.coli-20ug
QP5258-20ug 20ug
EUR 237.00

Recombinant Human MIP-3 beta/ CCL19 Protein, Untagged, E.coli-500ug
QP5258-500ug 500ug
EUR 1778.00

Recombinant Human MIP-3 beta/ CCL19 Protein, Untagged, E.coli-5ug
QP5258-5ug 5ug
EUR 136.00

Anti-beta 2 Microglobulin/B2m Antibody
A00456-3 100ug/vial
EUR 294.00

Recombinant Human IL-1 Beta Protein
PROTP01584-3 10ug
EUR 317.00
Description: IL-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant human IL-1β is a 17.3 kDa protein containing 153 amino acid residues.

Anti-Beta Tubulin Antibody (monoclonal, 5E4)
M01857-3 100ug/vial
EUR 294.00

Equine IL-1 beta Recombinant Protein
R00101-3 5ug/vial
EUR 259.00
Description: IL-1 beta (IL-1β) is a member of the interleukin 1 family of cytokines. The IL-1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. Equine IL-1 beta Recombinant Protein is purified interleukin-1 beta cytokine produced in yeast.

Recombinant Human TNF-Beta (E.coli-derived) Protein
PROTP01374-3 20ug
EUR 317.00
Description: TNF-β is a potent mediator of inflammatory and immune responses. It belongs to the TNF family of ligands and signals through TNFR1 and TNFR2. TNF-β is produced by activated T and B lymphocytes, and has similar activities to TNF-α. Like TNF-α, TNF-β is involved in the regulation of various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNF-β is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-β, which effectively anchors the TNF-β to the cell surface. TNF-β is cytotoxic to a wide range of tumor cells. Recombinant human TNF-β is a secreted 171 amino acid protein (18.6 kDa) which forms an active non-disulfide linked homotrimer structure in solution.

Mip/ Rat Mip ELISA Kit
ELI-23038r 96 Tests
EUR 886.00

1 mm 6-well Comb, RM
2328375 3unit
EUR 255.00

1 mm 8-well Comb, RM
2328376 3unit
EUR 255.00

1 mm 20-well Comb, RM
2328422 3unit
EUR 311.00

1 mm 10-well Comb, RM
2328948 3unit
EUR 288.00

A-M310 agarGEL RM, 10/pk
2332200 2unit
EUR 351.00
Description: pH 3 - 10

A-M38 agarGEL RM, 10/pk
2332210 2unit
EUR 351.00
Description: pH 3 - 8

A-M58 agarGEL RM, 10/pk
2332220 2unit
EUR 351.00
Description: pH 5 - 8

A-M510 agarGEL RM, 10/pk
2332230 2unit
EUR 351.00
Description: pH 5 - 10

1 mm Plate Set, RM-10
2398214 3unit
EUR 281.00
Description: 1 pai r of gl ass pl at es + 1 gask et , for 1 mm gel

0.75mm Glass plates 2/pk,RM
2398228 2unit
EUR 279.00
Description: N ot ched pl at e wi t h 0.75mm si de-spacer s

2mm Glass plates 2/pk, RM
2398236 2unit
EUR 249.00
Description: N ot ched pl at e wi t h 2mm si de-spacer s

0.75mm 12-well Combs 2pk,RM
2398271 2unit
EUR 269.00

MIP-3b Macrophage Inflammatory Protein-3 Beta Mouse Recombinant Protein (CCL19)
PROTO70460 Regular: 20ug
EUR 317.00
Description: Macrophage Inflammatory Protein-3 beta Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 83 amino acids and having a molecular mass of 9216 Dalton. ;The MIP-3b is purified by proprietary chromatographic techniques.

MIP-3b Macrophage Inflammatory Protein-3 Beta Human Recombinant Protein (CCL19)
PROTQ99731 Regular: 20ug
EUR 317.00
Description: Macrophage Inflammatory Protein-3 beta Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 77 amino acids and having a molecular mass of 8.8kDa. ;The MIP-3b is purified by proprietary chromatographic techniques.

Recombinant Human TGF-Beta 2 (mammalian derived) Protein
PROTP61812-3 10ug
EUR 317.00
Description: The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development. Recombinant human TGF-β2 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.

ELISA kit for Human CCL4/MIP-1 Beta
EK5189 96 tests
EUR 553.00
Description: Enzyme-linked immunosorbent assay kit for quantification of Human CCL4/MIP-1 Beta in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Rat CCL4/MIP-1 Beta
EK5423 96 tests
EUR 553.00
Description: Enzyme-linked immunosorbent assay kit for quantification of Rat CCL4/MIP-1 Beta in samples from serum, plasma, tissue homogenates and other biological fluids.

Human CCL4/MIP-1 beta PicoKine ELISA Kit
EK0450 96 wells
EUR 425.00
Description: For quantitative detection of human CCL4 in cell culture supernates, serum and plasma(heparin, EDTA, citrate).

Rat CCL4/MIP-1 beta PicoKine ELISA Kit
EK0939 96 wells
EUR 425.00
Description: For quantitative detection of rat CCL4 in cell culture supernates, serum and plasma(heparin, EDTA, citrate).

Rabbit Anti Human Mip-1 Beta Polyclonal Antibody
CPBT-65212RH 0.1 mg
EUR 881.00

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